Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management

Renal cell carcinoma is a term that represents multiple different disease processes, each driven by different genetic alterations, with distinct histology, and biological potential which necessitates divergent management strategies. This review discusses the genetic alterations seen in several forms...

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Detalles Bibliográficos
Autores principales: Gomella, Patrick T., Linehan, W. Marston, Ball, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916897/
https://www.ncbi.nlm.nih.gov/pubmed/33670168
http://dx.doi.org/10.3390/genes12020261
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author Gomella, Patrick T.
Linehan, W. Marston
Ball, Mark W.
author_facet Gomella, Patrick T.
Linehan, W. Marston
Ball, Mark W.
author_sort Gomella, Patrick T.
collection PubMed
description Renal cell carcinoma is a term that represents multiple different disease processes, each driven by different genetic alterations, with distinct histology, and biological potential which necessitates divergent management strategies. This review discusses the genetic alterations seen in several forms of hereditary kidney cancer and how that knowledge can dictate when and how to intervene with a focus on the surgical management of these tumors.
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spelling pubmed-79168972021-03-01 Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management Gomella, Patrick T. Linehan, W. Marston Ball, Mark W. Genes (Basel) Review Renal cell carcinoma is a term that represents multiple different disease processes, each driven by different genetic alterations, with distinct histology, and biological potential which necessitates divergent management strategies. This review discusses the genetic alterations seen in several forms of hereditary kidney cancer and how that knowledge can dictate when and how to intervene with a focus on the surgical management of these tumors. MDPI 2021-02-11 /pmc/articles/PMC7916897/ /pubmed/33670168 http://dx.doi.org/10.3390/genes12020261 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Gomella, Patrick T.
Linehan, W. Marston
Ball, Mark W.
Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management
title Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management
title_full Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management
title_fullStr Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management
title_full_unstemmed Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management
title_short Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management
title_sort precision surgery and kidney cancer: knowledge of genetic alterations influences surgical management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916897/
https://www.ncbi.nlm.nih.gov/pubmed/33670168
http://dx.doi.org/10.3390/genes12020261
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