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Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Studies have shown that glycerophospholipids are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study adopted targeted metabolomic analysis to investigate the changes in serum glycerophospholipids in acute exacerbation of chronic obstructive pulmonary disease (AEC...

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Autores principales: Gai, Xiaoyan, Guo, Chenglin, Zhang, Linlin, Zhang, Lijiao, Abulikemu, Mairipaiti, Wang, Juan, Zhou, Qingtao, Chen, Yahong, Sun, Yongchang, Chang, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917046/
https://www.ncbi.nlm.nih.gov/pubmed/33658945
http://dx.doi.org/10.3389/fphys.2021.646010
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author Gai, Xiaoyan
Guo, Chenglin
Zhang, Linlin
Zhang, Lijiao
Abulikemu, Mairipaiti
Wang, Juan
Zhou, Qingtao
Chen, Yahong
Sun, Yongchang
Chang, Chun
author_facet Gai, Xiaoyan
Guo, Chenglin
Zhang, Linlin
Zhang, Lijiao
Abulikemu, Mairipaiti
Wang, Juan
Zhou, Qingtao
Chen, Yahong
Sun, Yongchang
Chang, Chun
author_sort Gai, Xiaoyan
collection PubMed
description Studies have shown that glycerophospholipids are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study adopted targeted metabolomic analysis to investigate the changes in serum glycerophospholipids in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and their differential expression in patients with different inflammatory subtypes. Patients with AECOPD admitted between January 2015 and December 2017 were enrolled, and their clinical data were collected. The patients’ gender, age, body mass index, and lung function were recorded. Routine blood and induced sputum tests were performed. Liquid chromatography-mass spectrometry was used to detect the serum glycerophospholipid metabolic profiles and to analyze the metabolic profile changes between the acute exacerbation and recovery stages as well as the differences between different inflammatory subtypes. A total of 58 patients were hospitalized for AECOPD, including 49 male patients with a mean age of 74.8 ± 10.0 years. In the metabolic profiles, the expression of lysophosphatidylcholine (LPC) 18:3, lysophosphatidylethanolamine (LPE) 16:1, and phosphatidylinositol (PI) 32:1 was significantly reduced in the acute exacerbation stage compared to the recovery stage (P < 0.05). The three glycerophospholipids were used to plot the receiver operating characteristic curves to predict the acute exacerbation/recovery stage, and the areas under the curves were all above 70%. There were no differential metabolites between the two groups of patients with blood eosinophil percentage (EOS%) ≥2% and <2% at exacerbation. The expression of LPC 18:3, LPE 16:1, and PI 32:1 was significantly reduced in the acute exacerbation stage compared to the recovery stage in the inflammatory subtype with blood EOS <2% (P < 0.05). Abnormalities in the metabolism of glycerophospholipids may be involved in the onset of AECOPD, especially in the non-eosinophilic subtype.
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spelling pubmed-79170462021-03-02 Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Gai, Xiaoyan Guo, Chenglin Zhang, Linlin Zhang, Lijiao Abulikemu, Mairipaiti Wang, Juan Zhou, Qingtao Chen, Yahong Sun, Yongchang Chang, Chun Front Physiol Physiology Studies have shown that glycerophospholipids are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study adopted targeted metabolomic analysis to investigate the changes in serum glycerophospholipids in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and their differential expression in patients with different inflammatory subtypes. Patients with AECOPD admitted between January 2015 and December 2017 were enrolled, and their clinical data were collected. The patients’ gender, age, body mass index, and lung function were recorded. Routine blood and induced sputum tests were performed. Liquid chromatography-mass spectrometry was used to detect the serum glycerophospholipid metabolic profiles and to analyze the metabolic profile changes between the acute exacerbation and recovery stages as well as the differences between different inflammatory subtypes. A total of 58 patients were hospitalized for AECOPD, including 49 male patients with a mean age of 74.8 ± 10.0 years. In the metabolic profiles, the expression of lysophosphatidylcholine (LPC) 18:3, lysophosphatidylethanolamine (LPE) 16:1, and phosphatidylinositol (PI) 32:1 was significantly reduced in the acute exacerbation stage compared to the recovery stage (P < 0.05). The three glycerophospholipids were used to plot the receiver operating characteristic curves to predict the acute exacerbation/recovery stage, and the areas under the curves were all above 70%. There were no differential metabolites between the two groups of patients with blood eosinophil percentage (EOS%) ≥2% and <2% at exacerbation. The expression of LPC 18:3, LPE 16:1, and PI 32:1 was significantly reduced in the acute exacerbation stage compared to the recovery stage in the inflammatory subtype with blood EOS <2% (P < 0.05). Abnormalities in the metabolism of glycerophospholipids may be involved in the onset of AECOPD, especially in the non-eosinophilic subtype. Frontiers Media S.A. 2021-02-15 /pmc/articles/PMC7917046/ /pubmed/33658945 http://dx.doi.org/10.3389/fphys.2021.646010 Text en Copyright © 2021 Gai, Guo, Zhang, Zhang, Abulikemu, Wang, Zhou, Chen, Sun and Chang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Gai, Xiaoyan
Guo, Chenglin
Zhang, Linlin
Zhang, Lijiao
Abulikemu, Mairipaiti
Wang, Juan
Zhou, Qingtao
Chen, Yahong
Sun, Yongchang
Chang, Chun
Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
title Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
title_full Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
title_fullStr Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
title_full_unstemmed Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
title_short Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
title_sort serum glycerophospholipid profile in acute exacerbation of chronic obstructive pulmonary disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917046/
https://www.ncbi.nlm.nih.gov/pubmed/33658945
http://dx.doi.org/10.3389/fphys.2021.646010
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