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Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8(+) T Cells
Tissue-resident CD8(+) T cells (CD8(+) T(RM)) populate lymphoid and non-lymphoid tissues after infections as first line of defense against re-emerging pathogens. To achieve host protection, CD8(+) T(RM) have developed surveillance strategies that combine dynamic interrogation of pMHC complexes on lo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917134/ https://www.ncbi.nlm.nih.gov/pubmed/33659008 http://dx.doi.org/10.3389/fimmu.2021.626019 |
Sumario: | Tissue-resident CD8(+) T cells (CD8(+) T(RM)) populate lymphoid and non-lymphoid tissues after infections as first line of defense against re-emerging pathogens. To achieve host protection, CD8(+) T(RM) have developed surveillance strategies that combine dynamic interrogation of pMHC complexes on local stromal and hematopoietic cells with long-term residency. Factors mediating CD8(+) T(RM) residency include CD69, a surface receptor opposing the egress-promoting S1P1, CD49a, a collagen-binding integrin, and CD103, which binds E-cadherin on epithelial cells. Moreover, the topography of the tissues of residency may influence T(RM) retention and surveillance strategies. Here, we provide a brief summary of these factors to examine how CD8(+) T(RM) reconcile constant migratory behavior with their long-term commitment to local microenvironments, with a focus on epithelial barrier organs and exocrine glands with mixed connective—epithelial tissue composition. |
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