Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity...

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Detalles Bibliográficos
Autores principales: Wang, Daxi, Wang, Yanqun, Sun, Wanying, Zhang, Lu, Ji, Jingkai, Zhang, Zhaoyong, Cheng, Xinyi, Li, Yimin, Xiao, Fei, Zhu, Airu, Zhong, Bei, Ruan, Shicong, Li, Jiandong, Ren, Peidi, Ou, Zhihua, Xiao, Minfeng, Li, Min, Deng, Ziqing, Zhong, Huanzi, Li, Fuqiang, Wang, Wen-jing, Zhang, Yongwei, Chen, Weijun, Zhu, Shida, Xu, Xun, Jin, Xin, Zhao, Jingxian, Zhong, Nanshan, Zhang, Wenwei, Zhao, Jincun, Li, Junhua, Xu, Yonghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917136/
https://www.ncbi.nlm.nih.gov/pubmed/33659260
http://dx.doi.org/10.3389/fmed.2021.585358
Descripción
Sumario:The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.

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