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Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917136/ https://www.ncbi.nlm.nih.gov/pubmed/33659260 http://dx.doi.org/10.3389/fmed.2021.585358 |
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| author | Wang, Daxi Wang, Yanqun Sun, Wanying Zhang, Lu Ji, Jingkai Zhang, Zhaoyong Cheng, Xinyi Li, Yimin Xiao, Fei Zhu, Airu Zhong, Bei Ruan, Shicong Li, Jiandong Ren, Peidi Ou, Zhihua Xiao, Minfeng Li, Min Deng, Ziqing Zhong, Huanzi Li, Fuqiang Wang, Wen-jing Zhang, Yongwei Chen, Weijun Zhu, Shida Xu, Xun Jin, Xin Zhao, Jingxian Zhong, Nanshan Zhang, Wenwei Zhao, Jincun Li, Junhua Xu, Yonghao |
| author_facet | Wang, Daxi Wang, Yanqun Sun, Wanying Zhang, Lu Ji, Jingkai Zhang, Zhaoyong Cheng, Xinyi Li, Yimin Xiao, Fei Zhu, Airu Zhong, Bei Ruan, Shicong Li, Jiandong Ren, Peidi Ou, Zhihua Xiao, Minfeng Li, Min Deng, Ziqing Zhong, Huanzi Li, Fuqiang Wang, Wen-jing Zhang, Yongwei Chen, Weijun Zhu, Shida Xu, Xun Jin, Xin Zhao, Jingxian Zhong, Nanshan Zhang, Wenwei Zhao, Jincun Li, Junhua Xu, Yonghao |
| author_sort | Wang, Daxi |
| collection | PubMed |
| description | The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions. |
| format | Online Article Text |
| id | pubmed-7917136 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79171362021-03-02 Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 Wang, Daxi Wang, Yanqun Sun, Wanying Zhang, Lu Ji, Jingkai Zhang, Zhaoyong Cheng, Xinyi Li, Yimin Xiao, Fei Zhu, Airu Zhong, Bei Ruan, Shicong Li, Jiandong Ren, Peidi Ou, Zhihua Xiao, Minfeng Li, Min Deng, Ziqing Zhong, Huanzi Li, Fuqiang Wang, Wen-jing Zhang, Yongwei Chen, Weijun Zhu, Shida Xu, Xun Jin, Xin Zhao, Jingxian Zhong, Nanshan Zhang, Wenwei Zhao, Jincun Li, Junhua Xu, Yonghao Front Med (Lausanne) Medicine The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions. Frontiers Media S.A. 2021-02-15 /pmc/articles/PMC7917136/ /pubmed/33659260 http://dx.doi.org/10.3389/fmed.2021.585358 Text en Copyright © 2021 Wang, Wang, Sun, Zhang, Ji, Zhang, Cheng, Li, Xiao, Zhu, Zhong, Ruan, Li, Ren, Ou, Xiao, Li, Deng, Zhong, Li, Wang, Zhang, Chen, Zhu, Xu, Jin, Zhao, Zhong, Zhang, Zhao, Li and Xu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Medicine Wang, Daxi Wang, Yanqun Sun, Wanying Zhang, Lu Ji, Jingkai Zhang, Zhaoyong Cheng, Xinyi Li, Yimin Xiao, Fei Zhu, Airu Zhong, Bei Ruan, Shicong Li, Jiandong Ren, Peidi Ou, Zhihua Xiao, Minfeng Li, Min Deng, Ziqing Zhong, Huanzi Li, Fuqiang Wang, Wen-jing Zhang, Yongwei Chen, Weijun Zhu, Shida Xu, Xun Jin, Xin Zhao, Jingxian Zhong, Nanshan Zhang, Wenwei Zhao, Jincun Li, Junhua Xu, Yonghao Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 |
| title | Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 |
| title_full | Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 |
| title_fullStr | Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 |
| title_full_unstemmed | Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 |
| title_short | Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2 |
| title_sort | population bottlenecks and intra-host evolution during human-to-human transmission of sars-cov-2 |
| topic | Medicine |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917136/ https://www.ncbi.nlm.nih.gov/pubmed/33659260 http://dx.doi.org/10.3389/fmed.2021.585358 |
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