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Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome

Background: Local field potential (LFP) recordings helped to clarify the pathophysiology of Tourette syndrome (TS) and to define new strategies for deep brain stimulation (DBS) treatment for refractory TS, based on the delivery of stimulation in accordance with changes in the electrical activity of...

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Autores principales: Marceglia, Sara, Prenassi, Marco, Galbiati, Tommaso F., Porta, Mauro, Zekaj, Edvin, Priori, Alberto, Servello, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917178/
https://www.ncbi.nlm.nih.gov/pubmed/33658970
http://dx.doi.org/10.3389/fneur.2021.578324
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author Marceglia, Sara
Prenassi, Marco
Galbiati, Tommaso F.
Porta, Mauro
Zekaj, Edvin
Priori, Alberto
Servello, Domenico
author_facet Marceglia, Sara
Prenassi, Marco
Galbiati, Tommaso F.
Porta, Mauro
Zekaj, Edvin
Priori, Alberto
Servello, Domenico
author_sort Marceglia, Sara
collection PubMed
description Background: Local field potential (LFP) recordings helped to clarify the pathophysiology of Tourette syndrome (TS) and to define new strategies for deep brain stimulation (DBS) treatment for refractory TS, based on the delivery of stimulation in accordance with changes in the electrical activity of the DBS target area. However, there is little evidence on the relationship between LFP pattern and DBS outcomes in TS. Objective: To investigate the relationship between LFP oscillations and DBS effects on tics and on obsessive compulsive behavior (OCB) comorbidities. Methods: We retrospectively analyzed clinical data and LFP recordings from 17 patients treated with DBS of the centromedian-parafascicular/ventralis oralis (CM-Pf/VO) complex, and followed for more several years after DBS in the treating center. In these patients, LFPs were recorded either in the acute setting (3–5 days after DBS electrode implant) or in the chronic setting (during impulse generator replacement surgery). LFP oscillations were correlated with the Yale Global Tic Severity Scale (YGTSS) and the Yale–Brown Obsessive–Compulsive Scale (Y-BOCS) collected at baseline (before DBS surgery), 1 year after DBS, and at the last follow-up available. Results: We found that, at baseline, in the acute setting, the power of the oscillations included in the 5–15-Hz band, previously identified as TS biomarker, is correlated with the pathophysiology of tics, being significantly correlated with total YGTSS before DBS (Spearman's ρ = 0.701, p = 0.011). The power in the 5–15-Hz band was also correlated with the improvement in Y-BOCS after 1 year of DBS (Spearman's ρ = −0.587, p = 0.045), thus suggesting a relationship with the DBS effects on OCB comorbidities. Conclusions: Our observations confirm that the low-frequency (5–15-Hz) band is a significant biomarker of TS, being related to the severity of tics and, also to the long-term response on OCBs. This represents a step toward both the understanding of the mechanisms underlying DBS effects in TS and the development of adaptive DBS strategies.
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spelling pubmed-79171782021-03-02 Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome Marceglia, Sara Prenassi, Marco Galbiati, Tommaso F. Porta, Mauro Zekaj, Edvin Priori, Alberto Servello, Domenico Front Neurol Neurology Background: Local field potential (LFP) recordings helped to clarify the pathophysiology of Tourette syndrome (TS) and to define new strategies for deep brain stimulation (DBS) treatment for refractory TS, based on the delivery of stimulation in accordance with changes in the electrical activity of the DBS target area. However, there is little evidence on the relationship between LFP pattern and DBS outcomes in TS. Objective: To investigate the relationship between LFP oscillations and DBS effects on tics and on obsessive compulsive behavior (OCB) comorbidities. Methods: We retrospectively analyzed clinical data and LFP recordings from 17 patients treated with DBS of the centromedian-parafascicular/ventralis oralis (CM-Pf/VO) complex, and followed for more several years after DBS in the treating center. In these patients, LFPs were recorded either in the acute setting (3–5 days after DBS electrode implant) or in the chronic setting (during impulse generator replacement surgery). LFP oscillations were correlated with the Yale Global Tic Severity Scale (YGTSS) and the Yale–Brown Obsessive–Compulsive Scale (Y-BOCS) collected at baseline (before DBS surgery), 1 year after DBS, and at the last follow-up available. Results: We found that, at baseline, in the acute setting, the power of the oscillations included in the 5–15-Hz band, previously identified as TS biomarker, is correlated with the pathophysiology of tics, being significantly correlated with total YGTSS before DBS (Spearman's ρ = 0.701, p = 0.011). The power in the 5–15-Hz band was also correlated with the improvement in Y-BOCS after 1 year of DBS (Spearman's ρ = −0.587, p = 0.045), thus suggesting a relationship with the DBS effects on OCB comorbidities. Conclusions: Our observations confirm that the low-frequency (5–15-Hz) band is a significant biomarker of TS, being related to the severity of tics and, also to the long-term response on OCBs. This represents a step toward both the understanding of the mechanisms underlying DBS effects in TS and the development of adaptive DBS strategies. Frontiers Media S.A. 2021-02-15 /pmc/articles/PMC7917178/ /pubmed/33658970 http://dx.doi.org/10.3389/fneur.2021.578324 Text en Copyright © 2021 Marceglia, Prenassi, Galbiati, Porta, Zekaj, Priori and Servello. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Marceglia, Sara
Prenassi, Marco
Galbiati, Tommaso F.
Porta, Mauro
Zekaj, Edvin
Priori, Alberto
Servello, Domenico
Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome
title Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome
title_full Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome
title_fullStr Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome
title_full_unstemmed Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome
title_short Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome
title_sort thalamic local field potentials are related to long-term dbs effects in tourette syndrome
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917178/
https://www.ncbi.nlm.nih.gov/pubmed/33658970
http://dx.doi.org/10.3389/fneur.2021.578324
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