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Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2(−/−) Mice

The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response. OCT1 variants with decreased in vitro function correlate well with altered exposure of multiple OCT1 substrates in variant carriers. In t...

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Detalles Bibliográficos
Autores principales:	Morse, Bridget L., Chen, Lisa Hong, Catlow, John T., Fallon, John K., Smith, Philip C., Hillgren, Kathleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917185/ https://www.ncbi.nlm.nih.gov/pubmed/33658943 http://dx.doi.org/10.3389/fphar.2021.631793

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