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Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline

Individuals with subjective cognitive decline (SCD) are at higher risk of incipient Alzheimer's disease (AD). Spatial navigation (SN) impairments in AD dementia and mild cognitive impairment patients have been well-documented; however, studies investigating SN deficits in SCD subjects are still...

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Autores principales: Chen, Qian, Wu, Sichu, Li, Xin, Sun, Yi, Chen, Wenqian, Lu, Jiaming, Zhang, Wen, Liu, Jiani, Qing, Zhao, Nedelska, Zuzana, Hort, Jakub, Zhang, Xin, Zhang, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917187/
https://www.ncbi.nlm.nih.gov/pubmed/33658916
http://dx.doi.org/10.3389/fnagi.2021.596025
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author Chen, Qian
Wu, Sichu
Li, Xin
Sun, Yi
Chen, Wenqian
Lu, Jiaming
Zhang, Wen
Liu, Jiani
Qing, Zhao
Nedelska, Zuzana
Hort, Jakub
Zhang, Xin
Zhang, Bing
author_facet Chen, Qian
Wu, Sichu
Li, Xin
Sun, Yi
Chen, Wenqian
Lu, Jiaming
Zhang, Wen
Liu, Jiani
Qing, Zhao
Nedelska, Zuzana
Hort, Jakub
Zhang, Xin
Zhang, Bing
author_sort Chen, Qian
collection PubMed
description Individuals with subjective cognitive decline (SCD) are at higher risk of incipient Alzheimer's disease (AD). Spatial navigation (SN) impairments in AD dementia and mild cognitive impairment patients have been well-documented; however, studies investigating SN deficits in SCD subjects are still lacking. This study aimed to explore whether basal forebrain (BF) and entorhinal cortex (EC) atrophy contribute to spatial disorientation in the SCD stage. In total, 31 SCD subjects and 24 normal controls were enrolled and administered cognitive scales, a 2-dimensional computerized SN test, and structural magnetic resonance imaging (MRI) scanning. We computed the differences in navigation distance errors and volumes of BF subfields, EC, and hippocampus between the SCD and control groups. The correlations between MRI volumetry and navigation distance errors were also calculated. Compared with the controls, the SCD subjects performed worse in both egocentric and allocentric navigation. The SCD group showed volume reductions in the whole BF (p < 0.05, uncorrected) and the Ch4p subfield (p < 0.05, Bonferroni corrected), but comparable EC and hippocampal volumes with the controls. In the SCD cohort, the allocentric errors were negatively correlated with total BF (r = −0.625, p < 0.001), Ch4p (r = −0.625, p < 0.001), total EC (r = −0.423, p = 0.031), and left EC volumes (r = −0.442, p = 0.024), adjusting for age, gender, years of education, total intracranial volume, and hippocampal volume. This study demonstrates that SN deficits and BF atrophy may be promising indicators for the early detection of incipient AD patients. The reduced BF volume, especially in the Ch4p subfield, may serve as a structural basis for allocentric disorientation in SCD subjects independent of hippocampal atrophy. Our findings may have further implications for the preclinical diagnosis and intervention for potential AD patients.
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spelling pubmed-79171872021-03-02 Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline Chen, Qian Wu, Sichu Li, Xin Sun, Yi Chen, Wenqian Lu, Jiaming Zhang, Wen Liu, Jiani Qing, Zhao Nedelska, Zuzana Hort, Jakub Zhang, Xin Zhang, Bing Front Aging Neurosci Neuroscience Individuals with subjective cognitive decline (SCD) are at higher risk of incipient Alzheimer's disease (AD). Spatial navigation (SN) impairments in AD dementia and mild cognitive impairment patients have been well-documented; however, studies investigating SN deficits in SCD subjects are still lacking. This study aimed to explore whether basal forebrain (BF) and entorhinal cortex (EC) atrophy contribute to spatial disorientation in the SCD stage. In total, 31 SCD subjects and 24 normal controls were enrolled and administered cognitive scales, a 2-dimensional computerized SN test, and structural magnetic resonance imaging (MRI) scanning. We computed the differences in navigation distance errors and volumes of BF subfields, EC, and hippocampus between the SCD and control groups. The correlations between MRI volumetry and navigation distance errors were also calculated. Compared with the controls, the SCD subjects performed worse in both egocentric and allocentric navigation. The SCD group showed volume reductions in the whole BF (p < 0.05, uncorrected) and the Ch4p subfield (p < 0.05, Bonferroni corrected), but comparable EC and hippocampal volumes with the controls. In the SCD cohort, the allocentric errors were negatively correlated with total BF (r = −0.625, p < 0.001), Ch4p (r = −0.625, p < 0.001), total EC (r = −0.423, p = 0.031), and left EC volumes (r = −0.442, p = 0.024), adjusting for age, gender, years of education, total intracranial volume, and hippocampal volume. This study demonstrates that SN deficits and BF atrophy may be promising indicators for the early detection of incipient AD patients. The reduced BF volume, especially in the Ch4p subfield, may serve as a structural basis for allocentric disorientation in SCD subjects independent of hippocampal atrophy. Our findings may have further implications for the preclinical diagnosis and intervention for potential AD patients. Frontiers Media S.A. 2021-02-15 /pmc/articles/PMC7917187/ /pubmed/33658916 http://dx.doi.org/10.3389/fnagi.2021.596025 Text en Copyright © 2021 Chen, Wu, Li, Sun, Chen, Lu, Zhang, Liu, Qing, Nedelska, Hort, Zhang and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chen, Qian
Wu, Sichu
Li, Xin
Sun, Yi
Chen, Wenqian
Lu, Jiaming
Zhang, Wen
Liu, Jiani
Qing, Zhao
Nedelska, Zuzana
Hort, Jakub
Zhang, Xin
Zhang, Bing
Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline
title Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline
title_full Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline
title_fullStr Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline
title_full_unstemmed Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline
title_short Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline
title_sort basal forebrain atrophy is associated with allocentric navigation deficits in subjective cognitive decline
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917187/
https://www.ncbi.nlm.nih.gov/pubmed/33658916
http://dx.doi.org/10.3389/fnagi.2021.596025
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