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Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population

Background: Recent studies suggest that glycogen synthase kinase (GSK)-3β is involved in the development of major depressive disorder (MDD). The aim of this study was to investigate the interaction between GSK-3β polymorphism (rs6438552, rs334558, and rs2199503) and negative life events in the patho...

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Autores principales: Yang, Jiarun, Ke, Siyuan, Qiao, Zhengxue, Yang, Xiuxian, Qiu, Xiaohui, Song, Xuejia, Zhao, Erying, Zhou, Jiawei, Zhao, Mingzhe, Yang, Yanjie, Fang, Deyu, Cao, Depin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917206/
https://www.ncbi.nlm.nih.gov/pubmed/33658947
http://dx.doi.org/10.3389/fpsyt.2020.503477
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author Yang, Jiarun
Ke, Siyuan
Qiao, Zhengxue
Yang, Xiuxian
Qiu, Xiaohui
Song, Xuejia
Zhao, Erying
Zhou, Jiawei
Zhao, Mingzhe
Yang, Yanjie
Fang, Deyu
Cao, Depin
author_facet Yang, Jiarun
Ke, Siyuan
Qiao, Zhengxue
Yang, Xiuxian
Qiu, Xiaohui
Song, Xuejia
Zhao, Erying
Zhou, Jiawei
Zhao, Mingzhe
Yang, Yanjie
Fang, Deyu
Cao, Depin
author_sort Yang, Jiarun
collection PubMed
description Background: Recent studies suggest that glycogen synthase kinase (GSK)-3β is involved in the development of major depressive disorder (MDD). The aim of this study was to investigate the interaction between GSK-3β polymorphism (rs6438552, rs334558, and rs2199503) and negative life events in the pathogenesis of major depressive disorder (MDD). Methods: DNA genotyping was performed on peripheral blood leukocytes in 550 patients with MDD and 552 age- and gender-matched controls. The frequency and severity of negative life events were assessed by the Life Events Scale (LES). A chi-square method was employed to assess the gene-environment interaction (G × E). Results: Differences in rs6438552, rs334558, and rs2199503 genotype distributions were observed between MDD patients and controls. Significant G × E interactions between allelic variation of rs6438552, rs334558, and rs2199503 and negative life events were observed. Individuals with negative life events and carrying genotypes of rs6438552 A(+), rs334558 A(+), and rs2199503G(+) have increased the risk of depression. Conclusions: These results indicate that interactions between the GSK-3β rs6438552, rs334558, and rs2199503 polymorphisms and environment increases the risk of developing MDD.
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spelling pubmed-79172062021-03-02 Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population Yang, Jiarun Ke, Siyuan Qiao, Zhengxue Yang, Xiuxian Qiu, Xiaohui Song, Xuejia Zhao, Erying Zhou, Jiawei Zhao, Mingzhe Yang, Yanjie Fang, Deyu Cao, Depin Front Psychiatry Psychiatry Background: Recent studies suggest that glycogen synthase kinase (GSK)-3β is involved in the development of major depressive disorder (MDD). The aim of this study was to investigate the interaction between GSK-3β polymorphism (rs6438552, rs334558, and rs2199503) and negative life events in the pathogenesis of major depressive disorder (MDD). Methods: DNA genotyping was performed on peripheral blood leukocytes in 550 patients with MDD and 552 age- and gender-matched controls. The frequency and severity of negative life events were assessed by the Life Events Scale (LES). A chi-square method was employed to assess the gene-environment interaction (G × E). Results: Differences in rs6438552, rs334558, and rs2199503 genotype distributions were observed between MDD patients and controls. Significant G × E interactions between allelic variation of rs6438552, rs334558, and rs2199503 and negative life events were observed. Individuals with negative life events and carrying genotypes of rs6438552 A(+), rs334558 A(+), and rs2199503G(+) have increased the risk of depression. Conclusions: These results indicate that interactions between the GSK-3β rs6438552, rs334558, and rs2199503 polymorphisms and environment increases the risk of developing MDD. Frontiers Media S.A. 2021-02-15 /pmc/articles/PMC7917206/ /pubmed/33658947 http://dx.doi.org/10.3389/fpsyt.2020.503477 Text en Copyright © 2021 Yang, Ke, Qiao, Yang, Qiu, Song, Zhao, Zhou, Zhao, Yang, Fang and Cao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Yang, Jiarun
Ke, Siyuan
Qiao, Zhengxue
Yang, Xiuxian
Qiu, Xiaohui
Song, Xuejia
Zhao, Erying
Zhou, Jiawei
Zhao, Mingzhe
Yang, Yanjie
Fang, Deyu
Cao, Depin
Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population
title Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population
title_full Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population
title_fullStr Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population
title_full_unstemmed Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population
title_short Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population
title_sort interactions between glycogen synthase kinase-3β gene polymorphisms, negative life events, and susceptibility to major depressive disorder in a chinese population
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917206/
https://www.ncbi.nlm.nih.gov/pubmed/33658947
http://dx.doi.org/10.3389/fpsyt.2020.503477
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