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Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus

BACKGROUND: Neuropathy is one of most common complications in diabetic patients. Diagnosis of diabetic neuropathy is essential for decreasing the rate of the disability and death. Neuron-specific enolase (NSE) is released from damaged neuronal cells and enters the blood circulation through an injure...

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Autores principales: Elsharkawy, Rasha Elbialy, Abdel Azim, Ghada Saed, Osman, Marwa Abdellah, Maghraby, Hend Maghraby, Mohamed, Rehab Abdelfattah, Abdelsalam, Eman Mahmoud, Ebrahem, Eman Elshohat, Seliem, Nora Mohamed Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917357/
https://www.ncbi.nlm.nih.gov/pubmed/33658784
http://dx.doi.org/10.2147/NDT.S284308
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author Elsharkawy, Rasha Elbialy
Abdel Azim, Ghada Saed
Osman, Marwa Abdellah
Maghraby, Hend Maghraby
Mohamed, Rehab Abdelfattah
Abdelsalam, Eman Mahmoud
Ebrahem, Eman Elshohat
Seliem, Nora Mohamed Ahmed
author_facet Elsharkawy, Rasha Elbialy
Abdel Azim, Ghada Saed
Osman, Marwa Abdellah
Maghraby, Hend Maghraby
Mohamed, Rehab Abdelfattah
Abdelsalam, Eman Mahmoud
Ebrahem, Eman Elshohat
Seliem, Nora Mohamed Ahmed
author_sort Elsharkawy, Rasha Elbialy
collection PubMed
description BACKGROUND: Neuropathy is one of most common complications in diabetic patients. Diagnosis of diabetic neuropathy is essential for decreasing the rate of the disability and death. Neuron-specific enolase (NSE) is released from damaged neuronal cells and enters the blood circulation through an injured blood brain barrier. Therefore, serum NSE can reflect the damage of neurons and brain tissue. OBJECTIVE: To evaluate peripheral polyneuropathy and cognitive function in Type 2 Diabetes Mellitus (T2DM) and correlate them with NSE level as a possible biomarker of diabetic neuropathy. SUBJECTS AND METHODS: Forty five T2DM patients with polyneuropathy were randomly recruited in this study compared to 45 healthy age and sex matched subjects as a control. Patients group were divided into two subgroups, 24 diabetic patients with painful peripheral neuropathy and 21 with painless peripheral neuropathy. All were subjected to clinical assessment by diabetic neuropathy symptom score, Dyck neuropathy grading, Mini-Mental State Examination (MMSE), assessment of HbA1c, NSE biomarker and neurophysiological assessment (nerve conduction study (NCS), event related potential (P300wave) and somatosensory evoked potential (SSEP) of the right median nerve). RESULTS: There were significant decrease in cognitive functions in diabetic patients compared to controls and a significant increase in NSE in diabetic patients. There were no significant difference between patients with painless and painful diabetic neuropathy as regard MMSE, HbA1c and NSE. There were significant correlation of P300 in diabetic patients with HbA1c and NSE. CONCLUSION: Neurophysiological assessment of diabetic patients by NCS, SSEP and P300 have well evaluation of cognitive functions, painless, and painful diabetic polyneuropathy. NSE is a beneficial biomarker in diabetic patients to pick up neurological complications.
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spelling pubmed-79173572021-03-02 Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus Elsharkawy, Rasha Elbialy Abdel Azim, Ghada Saed Osman, Marwa Abdellah Maghraby, Hend Maghraby Mohamed, Rehab Abdelfattah Abdelsalam, Eman Mahmoud Ebrahem, Eman Elshohat Seliem, Nora Mohamed Ahmed Neuropsychiatr Dis Treat Original Research BACKGROUND: Neuropathy is one of most common complications in diabetic patients. Diagnosis of diabetic neuropathy is essential for decreasing the rate of the disability and death. Neuron-specific enolase (NSE) is released from damaged neuronal cells and enters the blood circulation through an injured blood brain barrier. Therefore, serum NSE can reflect the damage of neurons and brain tissue. OBJECTIVE: To evaluate peripheral polyneuropathy and cognitive function in Type 2 Diabetes Mellitus (T2DM) and correlate them with NSE level as a possible biomarker of diabetic neuropathy. SUBJECTS AND METHODS: Forty five T2DM patients with polyneuropathy were randomly recruited in this study compared to 45 healthy age and sex matched subjects as a control. Patients group were divided into two subgroups, 24 diabetic patients with painful peripheral neuropathy and 21 with painless peripheral neuropathy. All were subjected to clinical assessment by diabetic neuropathy symptom score, Dyck neuropathy grading, Mini-Mental State Examination (MMSE), assessment of HbA1c, NSE biomarker and neurophysiological assessment (nerve conduction study (NCS), event related potential (P300wave) and somatosensory evoked potential (SSEP) of the right median nerve). RESULTS: There were significant decrease in cognitive functions in diabetic patients compared to controls and a significant increase in NSE in diabetic patients. There were no significant difference between patients with painless and painful diabetic neuropathy as regard MMSE, HbA1c and NSE. There were significant correlation of P300 in diabetic patients with HbA1c and NSE. CONCLUSION: Neurophysiological assessment of diabetic patients by NCS, SSEP and P300 have well evaluation of cognitive functions, painless, and painful diabetic polyneuropathy. NSE is a beneficial biomarker in diabetic patients to pick up neurological complications. Dove 2021-02-24 /pmc/articles/PMC7917357/ /pubmed/33658784 http://dx.doi.org/10.2147/NDT.S284308 Text en © 2021 Elsharkawy et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Elsharkawy, Rasha Elbialy
Abdel Azim, Ghada Saed
Osman, Marwa Abdellah
Maghraby, Hend Maghraby
Mohamed, Rehab Abdelfattah
Abdelsalam, Eman Mahmoud
Ebrahem, Eman Elshohat
Seliem, Nora Mohamed Ahmed
Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus
title Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus
title_full Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus
title_fullStr Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus
title_full_unstemmed Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus
title_short Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus
title_sort peripheral polyneuropathy and cognitive impairment in type ii diabetes mellitus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917357/
https://www.ncbi.nlm.nih.gov/pubmed/33658784
http://dx.doi.org/10.2147/NDT.S284308
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