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Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing

The majority of CD19-directed CAR T cell products are manufactured using an autologous process. Although using a patient's leukapheresis reduces the risks of rejection, it introduces variability in starting material composition and the presence of cell populations that might negatively affect p...

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Detalles Bibliográficos
Autores principales:	Noaks, Elsa, Peticone, Carlotta, Kotsopoulou, Ekaterini, Bracewell, Daniel G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917474/ https://www.ncbi.nlm.nih.gov/pubmed/33718517 http://dx.doi.org/10.1016/j.omtm.2021.02.002

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