An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model

Human papillomaviruses (HPVs) are responsible for about 25% of cancer cases worldwide. HPV-16 E7 antigen is a tumor-associated antigen (TAA) commonly expressed in HPV-induced tumors; however, it has low immunogenicity. The interaction of 4-1BBL with its receptor induces pleiotropic effects on innate...

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Detalles Bibliográficos
Autores principales: Martinez-Perez, Alejandra G., Perez-Trujillo, Jose J., Garza-Morales, Rodolfo, Ramirez-Avila, Norma E., Loera-Arias, Maria J., Gomez-Gutierrez, Jorge G., Saucedo-Cardenas, Odila, Garcia-Garcia, Aracely, Rodriguez-Rocha, Humberto, Montes-de-Oca-Luna, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917608/
https://www.ncbi.nlm.nih.gov/pubmed/33673295
http://dx.doi.org/10.3390/vaccines9020149

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