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Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells
The present article demonstrates selective cytotoxicity against cancer cells of the complexes [Co(L(D))(2)]I(2)∙CH(3)OH (1), [CoL(D)(NCS)(2)] (2) and [VOL(D)(NCS)(2)]∙C(6)H(5)CH(3) (3) containing the dipodal tridentate ligand LD = N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)amine), formed in situ. All te...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917659/ https://www.ncbi.nlm.nih.gov/pubmed/33670389 http://dx.doi.org/10.3390/ijms22041802 |
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author | Tyszka-Czochara, Malgorzata Adach, Anna Grabowski, Tomasz Konieczny, Paweł Pasko, Paweł Ortyl, Joanna Świergosz, Tomasz Majka, Marcin |
author_facet | Tyszka-Czochara, Malgorzata Adach, Anna Grabowski, Tomasz Konieczny, Paweł Pasko, Paweł Ortyl, Joanna Świergosz, Tomasz Majka, Marcin |
author_sort | Tyszka-Czochara, Malgorzata |
collection | PubMed |
description | The present article demonstrates selective cytotoxicity against cancer cells of the complexes [Co(L(D))(2)]I(2)∙CH(3)OH (1), [CoL(D)(NCS)(2)] (2) and [VOL(D)(NCS)(2)]∙C(6)H(5)CH(3) (3) containing the dipodal tridentate ligand LD = N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)amine), formed in situ. All tested complexes expressed greater anticancer activities and were less toxic towards noncancerous cells than cisplatin. Cobalt complexes (1 and 2) combined high cytotoxicity with selectivity towards cancer cells and caused massive tumour cell death. The vanadium complex (3) induced apoptosis specifically in cancer cells and targeted proteins, controlling their invasive and metastatic properties. The presented experimental data and computational prediction of drug ability of coordination compounds may be helpful for designing novel and less toxic metal-based anticancer species with high specificities towards tumour cells. |
format | Online Article Text |
id | pubmed-7917659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79176592021-03-02 Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells Tyszka-Czochara, Malgorzata Adach, Anna Grabowski, Tomasz Konieczny, Paweł Pasko, Paweł Ortyl, Joanna Świergosz, Tomasz Majka, Marcin Int J Mol Sci Article The present article demonstrates selective cytotoxicity against cancer cells of the complexes [Co(L(D))(2)]I(2)∙CH(3)OH (1), [CoL(D)(NCS)(2)] (2) and [VOL(D)(NCS)(2)]∙C(6)H(5)CH(3) (3) containing the dipodal tridentate ligand LD = N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)amine), formed in situ. All tested complexes expressed greater anticancer activities and were less toxic towards noncancerous cells than cisplatin. Cobalt complexes (1 and 2) combined high cytotoxicity with selectivity towards cancer cells and caused massive tumour cell death. The vanadium complex (3) induced apoptosis specifically in cancer cells and targeted proteins, controlling their invasive and metastatic properties. The presented experimental data and computational prediction of drug ability of coordination compounds may be helpful for designing novel and less toxic metal-based anticancer species with high specificities towards tumour cells. MDPI 2021-02-11 /pmc/articles/PMC7917659/ /pubmed/33670389 http://dx.doi.org/10.3390/ijms22041802 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tyszka-Czochara, Malgorzata Adach, Anna Grabowski, Tomasz Konieczny, Paweł Pasko, Paweł Ortyl, Joanna Świergosz, Tomasz Majka, Marcin Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells |
title | Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells |
title_full | Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells |
title_fullStr | Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells |
title_full_unstemmed | Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells |
title_short | Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells |
title_sort | selective cytotoxicity of complexes with n,n,n-donor dipodal ligand in tumor cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917659/ https://www.ncbi.nlm.nih.gov/pubmed/33670389 http://dx.doi.org/10.3390/ijms22041802 |
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