B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity

Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence-associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood,...

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Autores principales: Frasca, Daniela, Romero, Maria, Diaz, Alain, Garcia, Denisse, Thaller, Seth, Blomberg, Bonnie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917792/
https://www.ncbi.nlm.nih.gov/pubmed/33673271
http://dx.doi.org/10.3390/ijms22041839
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author Frasca, Daniela
Romero, Maria
Diaz, Alain
Garcia, Denisse
Thaller, Seth
Blomberg, Bonnie B.
author_facet Frasca, Daniela
Romero, Maria
Diaz, Alain
Garcia, Denisse
Thaller, Seth
Blomberg, Bonnie B.
author_sort Frasca, Daniela
collection PubMed
description Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence-associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper-metabolic profile necessary to support the increased immune activation of AT-derived B cells as compared to blood-derived B cells. This hyper-metabolic profile is needed for the secretion of the pro-inflammatory mediators (cytokines, chemokines, micro-RNAs) that fuel local and systemic inflammation.
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spelling pubmed-79177922021-03-02 B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity Frasca, Daniela Romero, Maria Diaz, Alain Garcia, Denisse Thaller, Seth Blomberg, Bonnie B. Int J Mol Sci Article Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence-associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper-metabolic profile necessary to support the increased immune activation of AT-derived B cells as compared to blood-derived B cells. This hyper-metabolic profile is needed for the secretion of the pro-inflammatory mediators (cytokines, chemokines, micro-RNAs) that fuel local and systemic inflammation. MDPI 2021-02-12 /pmc/articles/PMC7917792/ /pubmed/33673271 http://dx.doi.org/10.3390/ijms22041839 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Frasca, Daniela
Romero, Maria
Diaz, Alain
Garcia, Denisse
Thaller, Seth
Blomberg, Bonnie B.
B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
title B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
title_full B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
title_fullStr B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
title_full_unstemmed B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
title_short B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
title_sort b cells with a senescent-associated secretory phenotype accumulate in the adipose tissue of individuals with obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917792/
https://www.ncbi.nlm.nih.gov/pubmed/33673271
http://dx.doi.org/10.3390/ijms22041839
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