Complexation with Random Methyl-β-Cyclodextrin and (2-Hidroxypropyl)-β-Cyclodextrin Enhances In Vivo Anti-Fibrotic and Anti-Inflammatory Effects of Chrysin via the Inhibition of NF-κB and TGF-β1/Smad Signaling Pathways and Modulation of Hepatic Pro/Anti-Fibrotic miRNA

Chrysin (CHR) is a natural flavonoid with a wide range of pharmacological activities, including hepatoprotection, but poor water solubility. By including water-soluble hydroxypropyl (HPBCD) and randomly methylated (RAMEB) β-cyclodextrin, we aimed to increase its biodisponibility and the effectivenes...

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Detalles Bibliográficos
Autores principales: Ciceu, Alina, Balta, Cornel, Herman, Hidegard, Gharbia, Sami, Ignat, Simona-Rebeca, Dinescu, Sorina, Váradi, Judit, Fenyvesi, Ferenc, Gyöngyösi, Szilvia, Hermenean, Anca, Costache, Marieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917810/
https://www.ncbi.nlm.nih.gov/pubmed/33668543
http://dx.doi.org/10.3390/ijms22041869

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