The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors

The neonatal Fc receptor (FcRn) binds endogenous IgG and protects it from lysosomal degradation by transporting it back to the cell surface to re-enter the circulation, extending the serum IgG life span. FcRn plays a role in the function of IVIg because the supraphysiological IgG levels derived from...

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Detalles Bibliográficos
Autores principales: Dalakas, Marinos C., Spaeth, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917847/
https://www.ncbi.nlm.nih.gov/pubmed/33717213
http://dx.doi.org/10.1177/1756286421997381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917847/
https://www.ncbi.nlm.nih.gov/pubmed/33717213
http://dx.doi.org/10.1177/1756286421997381

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