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Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway

Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals. In this study, the abuse potential of quetiapine was assessed based...

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Autor principal: Althobaiti, Yusuf S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917861/
https://www.ncbi.nlm.nih.gov/pubmed/33672850
http://dx.doi.org/10.3390/ph14020156
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author Althobaiti, Yusuf S.
author_facet Althobaiti, Yusuf S.
author_sort Althobaiti, Yusuf S.
collection PubMed
description Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals. In this study, the abuse potential of quetiapine was assessed based on the conditioned place preference (CPP) paradigm of drug addiction in a mouse model. First, mice received intraperitoneal injections of quetiapine (40, 80, or 120 mg/kg) every other day during the conditioning phase. In the second experiment, mice were pretreated with 0.03 mg/kg SKF-35866, a D1 receptor antagonist, before receiving saline or quetiapine (120 mg/kg) during the conditioning phase. No significant changes in time spent in the quetiapine-paired chamber were observed compared with time spent in the saline-paired chamber in mice treated with 40 or 80 mg/kg. In contrast, the preference to the quetiapine-paired chamber was significantly increased in mice treated with 120 mg/kg quetiapine, and this effect was blocked by SKF-35866 pretreatment. These results demonstrated, for the first time, the abuse potential of quetiapine in an animal model of drug addiction. Interestingly, this CPP-inducing effect was likely mediated by activating D1 receptors.
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spelling pubmed-79178612021-03-02 Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway Althobaiti, Yusuf S. Pharmaceuticals (Basel) Article Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals. In this study, the abuse potential of quetiapine was assessed based on the conditioned place preference (CPP) paradigm of drug addiction in a mouse model. First, mice received intraperitoneal injections of quetiapine (40, 80, or 120 mg/kg) every other day during the conditioning phase. In the second experiment, mice were pretreated with 0.03 mg/kg SKF-35866, a D1 receptor antagonist, before receiving saline or quetiapine (120 mg/kg) during the conditioning phase. No significant changes in time spent in the quetiapine-paired chamber were observed compared with time spent in the saline-paired chamber in mice treated with 40 or 80 mg/kg. In contrast, the preference to the quetiapine-paired chamber was significantly increased in mice treated with 120 mg/kg quetiapine, and this effect was blocked by SKF-35866 pretreatment. These results demonstrated, for the first time, the abuse potential of quetiapine in an animal model of drug addiction. Interestingly, this CPP-inducing effect was likely mediated by activating D1 receptors. MDPI 2021-02-14 /pmc/articles/PMC7917861/ /pubmed/33672850 http://dx.doi.org/10.3390/ph14020156 Text en © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Althobaiti, Yusuf S.
Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway
title Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway
title_full Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway
title_fullStr Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway
title_full_unstemmed Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway
title_short Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway
title_sort quetiapine-induced place preference in mice: possible dopaminergic pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917861/
https://www.ncbi.nlm.nih.gov/pubmed/33672850
http://dx.doi.org/10.3390/ph14020156
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