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SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with multiple underlying diseases. Particularly epithelial damage results from direct (e.g., pneumonia) rather than indirect lung injury (e.g., nonpulmonary sepsis), which is more likely associated with endothelial damage. Hence,...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917979/ https://www.ncbi.nlm.nih.gov/pubmed/33673270 http://dx.doi.org/10.3390/jcm10040737 |
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author | Peukert, Konrad Seeliger, Benjamin Fox, Mario Feuerborn, Caroline Sauer, Andrea Schuss, Patrick Schneider, Matthias David, Sascha Welte, Tobias Putensen, Christian Wilhelm, Christoph Steinhagen, Folkert Bode, Christian |
author_facet | Peukert, Konrad Seeliger, Benjamin Fox, Mario Feuerborn, Caroline Sauer, Andrea Schuss, Patrick Schneider, Matthias David, Sascha Welte, Tobias Putensen, Christian Wilhelm, Christoph Steinhagen, Folkert Bode, Christian |
author_sort | Peukert, Konrad |
collection | PubMed |
description | Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with multiple underlying diseases. Particularly epithelial damage results from direct (e.g., pneumonia) rather than indirect lung injury (e.g., nonpulmonary sepsis), which is more likely associated with endothelial damage. Hence, targeting ARDS patients based on their molecular phenotypes is a promising approach to improve outcome. With regard to distinct inflammatory responses and subsequent lung damage in direct ARDS due to the causing pathogen, we quantified markers of epithelial and endothelial damage and pro-inflammatory cytokines in patients with ARDS triggered by bacterial, viral, and atypical pathogen pneumonia or indirect ARDS. The serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8), lung epithelial injury markers surfactant protein D (SP-D), and soluble receptor for advanced glycation end-products (sRAGE) as well as endothelial injury marker angiopoietin-2 (Ang-2) from 49 patients with distinct types of ARDS were analyzed by multiplex immunoassay. Epithelial damage marker SP-D was significantly higher in direct ARDS caused by viral and atypical pathogens in contrast to ARDS caused by typical bacterial pneumonia and nonpulmonary sepsis. In contrast, sRAGE levels did not differ due to the causing pathogen. Patients with atypical pathogen pneumonia related ARDS showed significantly lower Ang-2 levels compared to patients with viral and indirect ARDS. Patients with viral and atypical pneumonia related ARDS possessed significantly lower serum IL-6 levels compared to bacterial pneumonia related ARDS and IL-6 levels in atypical pneumonia related ARDS were significantly lower than in indirect ARDS. Current findings report a potential difference in ARDS biomarkers due to the underlying disease and pathogen. |
format | Online Article Text |
id | pubmed-7917979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79179792021-03-02 SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS Peukert, Konrad Seeliger, Benjamin Fox, Mario Feuerborn, Caroline Sauer, Andrea Schuss, Patrick Schneider, Matthias David, Sascha Welte, Tobias Putensen, Christian Wilhelm, Christoph Steinhagen, Folkert Bode, Christian J Clin Med Article Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with multiple underlying diseases. Particularly epithelial damage results from direct (e.g., pneumonia) rather than indirect lung injury (e.g., nonpulmonary sepsis), which is more likely associated with endothelial damage. Hence, targeting ARDS patients based on their molecular phenotypes is a promising approach to improve outcome. With regard to distinct inflammatory responses and subsequent lung damage in direct ARDS due to the causing pathogen, we quantified markers of epithelial and endothelial damage and pro-inflammatory cytokines in patients with ARDS triggered by bacterial, viral, and atypical pathogen pneumonia or indirect ARDS. The serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8), lung epithelial injury markers surfactant protein D (SP-D), and soluble receptor for advanced glycation end-products (sRAGE) as well as endothelial injury marker angiopoietin-2 (Ang-2) from 49 patients with distinct types of ARDS were analyzed by multiplex immunoassay. Epithelial damage marker SP-D was significantly higher in direct ARDS caused by viral and atypical pathogens in contrast to ARDS caused by typical bacterial pneumonia and nonpulmonary sepsis. In contrast, sRAGE levels did not differ due to the causing pathogen. Patients with atypical pathogen pneumonia related ARDS showed significantly lower Ang-2 levels compared to patients with viral and indirect ARDS. Patients with viral and atypical pneumonia related ARDS possessed significantly lower serum IL-6 levels compared to bacterial pneumonia related ARDS and IL-6 levels in atypical pneumonia related ARDS were significantly lower than in indirect ARDS. Current findings report a potential difference in ARDS biomarkers due to the underlying disease and pathogen. MDPI 2021-02-12 /pmc/articles/PMC7917979/ /pubmed/33673270 http://dx.doi.org/10.3390/jcm10040737 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Peukert, Konrad Seeliger, Benjamin Fox, Mario Feuerborn, Caroline Sauer, Andrea Schuss, Patrick Schneider, Matthias David, Sascha Welte, Tobias Putensen, Christian Wilhelm, Christoph Steinhagen, Folkert Bode, Christian SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS |
title | SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS |
title_full | SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS |
title_fullStr | SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS |
title_full_unstemmed | SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS |
title_short | SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS |
title_sort | sp-d serum levels reveal distinct epithelial damage in direct human ards |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917979/ https://www.ncbi.nlm.nih.gov/pubmed/33673270 http://dx.doi.org/10.3390/jcm10040737 |
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