Dysregulations of Expression of Genes of the Ubiquitin/SUMO Pathways in an In Vitro Model of Amyotrophic Lateral Sclerosis Combining Oxidative Stress and SOD1 Gene Mutation

Protein aggregates in affected motor neurons are a hallmark of amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to their formation remain incompletely understood. Oxidative stress associated with age, the major risk factor in ALS, contributes to this neurodegeneration in ALS....

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Detalles Bibliográficos
Autores principales: Dangoumau, Audrey, Marouillat, Sylviane, Coelho, Roxane, Wurmser, François, Brulard, Céline, Haouari, Shanez, Laumonnier, Frédéric, Corcia, Philippe, Andres, Christian R., Blasco, Hélène, Vourc’h, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918082/
https://www.ncbi.nlm.nih.gov/pubmed/33670299
http://dx.doi.org/10.3390/ijms22041796

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