Towards Non-Invasive Diagnosis of Skin Cancer: Sensing Depth Investigation of Open-Ended Coaxial Probes †

SIMPLE SUMMARY: This work investigates the effect of skin tissue heterogeneity on the sensing depth of the open-ended coaxial probe to exploit the potential use of the probe for skin cancer detection and to establish a simple measurement protocol for skin depth characterization. Skin depth was calculated through simulations and measurements. Heterogeneity was obtained using double-layered materials composed of gel-like skin mimicking material and liquid olive oil, triton X-100. It was concluded that the sensing depth was not dependent on the frequency between 0.5 to 6 GHz, was affected by the material located at the aperture of the probe, and lastly the dielectric property contrast between layers. Namely the degree of heterogeneity affects the probe sensing depth. ABSTRACT: Dielectric properties of biological tissues are traditionally measured with open-ended coaxial probes. Despite being commercially available for laboratory use, the technique suffers from high measurement error. This prevents the practical applications of the open-ended coaxial probes. One such application is the utilization of the technique for skin cancer detection. To enable a diagnostic tool, there is a need to address the error sources. Among others, tissue heterogeneity is a major contributor to measurement error. The effect of tissue heterogeneity on measurement accuracy can be decreased by quantifying the probe sensing depth. To this end, this work (1) investigates the sensing depth of the 2.2 mm-diameter open-ended coaxial probe for skin mimicking material and (2) offers a simple experimental setup and protocol for sensing depth characterization of open-ended coaxial probes. The sensing depth characterized through simulation and experiments using two double-layered configurations composed to mimic the skin tissue heterogeneity. Three thresholds in percent increase of dielectric property measurements were chosen to determine the sensing depth. Based on the experiment results, it was concluded that the sensing depth was effected by the dielectric property contrast between the layers. That is, high contrast results in rapid change whereas low contrast results in a slower change in measured dielectric properties. It was also concluded that the sensing depth was independent of frequency between 0.5 to 6 GHz and was mostly determined by the material located immediately at the aperture of the probe.