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Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter
A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of Proton Therapy, Institute Curie in Orsay, France....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918314/ https://www.ncbi.nlm.nih.gov/pubmed/33673115 http://dx.doi.org/10.3390/s21041314 |
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author | Loto, Oluwasayo Zahradnik, Izabella Leite, Amelia Maia De Marzi, Ludovic Tromson, Dominique Pomorski, Michal |
author_facet | Loto, Oluwasayo Zahradnik, Izabella Leite, Amelia Maia De Marzi, Ludovic Tromson, Dominique Pomorski, Michal |
author_sort | Loto, Oluwasayo |
collection | PubMed |
description | A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of Proton Therapy, Institute Curie in Orsay, France. To qualify the performance of the set-up in clinical conditions of hadrontherapy, the dose, dose rate and energy loss pulse-height spectra in a diamond microdosimeter were recorded at multiple points along depth of a water-equivalent plastic phantom. The dose-mean lineal energy ([Formula: see text]) values were computed from experimental data and compared to silicon on insulator (SOI) microdosimeter literature results. In addition, the measured dose profile, pulse height spectra and [Formula: see text] values were benchmarked with a numerical simulation using TOPAS and Geant4 toolkits. These first clinical tests of a novel system confirm that diamond is a promising candidate for a tissue equivalent, radiation hard, high spatial resolution microdosimeter in beam quality assurance of proton therapy. |
format | Online Article Text |
id | pubmed-7918314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79183142021-03-02 Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter Loto, Oluwasayo Zahradnik, Izabella Leite, Amelia Maia De Marzi, Ludovic Tromson, Dominique Pomorski, Michal Sensors (Basel) Communication A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of Proton Therapy, Institute Curie in Orsay, France. To qualify the performance of the set-up in clinical conditions of hadrontherapy, the dose, dose rate and energy loss pulse-height spectra in a diamond microdosimeter were recorded at multiple points along depth of a water-equivalent plastic phantom. The dose-mean lineal energy ([Formula: see text]) values were computed from experimental data and compared to silicon on insulator (SOI) microdosimeter literature results. In addition, the measured dose profile, pulse height spectra and [Formula: see text] values were benchmarked with a numerical simulation using TOPAS and Geant4 toolkits. These first clinical tests of a novel system confirm that diamond is a promising candidate for a tissue equivalent, radiation hard, high spatial resolution microdosimeter in beam quality assurance of proton therapy. MDPI 2021-02-12 /pmc/articles/PMC7918314/ /pubmed/33673115 http://dx.doi.org/10.3390/s21041314 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Loto, Oluwasayo Zahradnik, Izabella Leite, Amelia Maia De Marzi, Ludovic Tromson, Dominique Pomorski, Michal Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter |
title | Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter |
title_full | Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter |
title_fullStr | Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter |
title_full_unstemmed | Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter |
title_short | Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter |
title_sort | simultaneous measurements of dose and microdosimetric spectra in a clinical proton beam using a sccvd diamond membrane microdosimeter |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918314/ https://www.ncbi.nlm.nih.gov/pubmed/33673115 http://dx.doi.org/10.3390/s21041314 |
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