Cargando…

Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter

A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of Proton Therapy, Institute Curie in Orsay, France....

Descripción completa

Detalles Bibliográficos
Autores principales: Loto, Oluwasayo, Zahradnik, Izabella, Leite, Amelia Maia, De Marzi, Ludovic, Tromson, Dominique, Pomorski, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918314/
https://www.ncbi.nlm.nih.gov/pubmed/33673115
http://dx.doi.org/10.3390/s21041314
_version_ 1783657894613352448
author Loto, Oluwasayo
Zahradnik, Izabella
Leite, Amelia Maia
De Marzi, Ludovic
Tromson, Dominique
Pomorski, Michal
author_facet Loto, Oluwasayo
Zahradnik, Izabella
Leite, Amelia Maia
De Marzi, Ludovic
Tromson, Dominique
Pomorski, Michal
author_sort Loto, Oluwasayo
collection PubMed
description A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of Proton Therapy, Institute Curie in Orsay, France. To qualify the performance of the set-up in clinical conditions of hadrontherapy, the dose, dose rate and energy loss pulse-height spectra in a diamond microdosimeter were recorded at multiple points along depth of a water-equivalent plastic phantom. The dose-mean lineal energy ([Formula: see text]) values were computed from experimental data and compared to silicon on insulator (SOI) microdosimeter literature results. In addition, the measured dose profile, pulse height spectra and [Formula: see text] values were benchmarked with a numerical simulation using TOPAS and Geant4 toolkits. These first clinical tests of a novel system confirm that diamond is a promising candidate for a tissue equivalent, radiation hard, high spatial resolution microdosimeter in beam quality assurance of proton therapy.
format Online
Article
Text
id pubmed-7918314
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79183142021-03-02 Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter Loto, Oluwasayo Zahradnik, Izabella Leite, Amelia Maia De Marzi, Ludovic Tromson, Dominique Pomorski, Michal Sensors (Basel) Communication A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of Proton Therapy, Institute Curie in Orsay, France. To qualify the performance of the set-up in clinical conditions of hadrontherapy, the dose, dose rate and energy loss pulse-height spectra in a diamond microdosimeter were recorded at multiple points along depth of a water-equivalent plastic phantom. The dose-mean lineal energy ([Formula: see text]) values were computed from experimental data and compared to silicon on insulator (SOI) microdosimeter literature results. In addition, the measured dose profile, pulse height spectra and [Formula: see text] values were benchmarked with a numerical simulation using TOPAS and Geant4 toolkits. These first clinical tests of a novel system confirm that diamond is a promising candidate for a tissue equivalent, radiation hard, high spatial resolution microdosimeter in beam quality assurance of proton therapy. MDPI 2021-02-12 /pmc/articles/PMC7918314/ /pubmed/33673115 http://dx.doi.org/10.3390/s21041314 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Loto, Oluwasayo
Zahradnik, Izabella
Leite, Amelia Maia
De Marzi, Ludovic
Tromson, Dominique
Pomorski, Michal
Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter
title Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter
title_full Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter
title_fullStr Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter
title_full_unstemmed Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter
title_short Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter
title_sort simultaneous measurements of dose and microdosimetric spectra in a clinical proton beam using a sccvd diamond membrane microdosimeter
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918314/
https://www.ncbi.nlm.nih.gov/pubmed/33673115
http://dx.doi.org/10.3390/s21041314
work_keys_str_mv AT lotooluwasayo simultaneousmeasurementsofdoseandmicrodosimetricspectrainaclinicalprotonbeamusingasccvddiamondmembranemicrodosimeter
AT zahradnikizabella simultaneousmeasurementsofdoseandmicrodosimetricspectrainaclinicalprotonbeamusingasccvddiamondmembranemicrodosimeter
AT leiteameliamaia simultaneousmeasurementsofdoseandmicrodosimetricspectrainaclinicalprotonbeamusingasccvddiamondmembranemicrodosimeter
AT demarziludovic simultaneousmeasurementsofdoseandmicrodosimetricspectrainaclinicalprotonbeamusingasccvddiamondmembranemicrodosimeter
AT tromsondominique simultaneousmeasurementsofdoseandmicrodosimetricspectrainaclinicalprotonbeamusingasccvddiamondmembranemicrodosimeter
AT pomorskimichal simultaneousmeasurementsofdoseandmicrodosimetricspectrainaclinicalprotonbeamusingasccvddiamondmembranemicrodosimeter