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Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition

Pancreatic cancer remains intractable owing to the lack of effective therapy for unresectable cases. Activating mutations of K-ras are frequently found in pancreatic cancers, but these have not yet been targeted by cancer therapies. The Keap1-Nrf2 system plays a crucial role in mediating the oxidati...

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Detalles Bibliográficos
Autores principales:	Hamada, Shin, Matsumoto, Ryotaro, Tanaka, Yu, Taguchi, Keiko, Yamamoto, Masayuki, Masamune, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918355/ https://www.ncbi.nlm.nih.gov/pubmed/33672789 http://dx.doi.org/10.3390/ijms22041870

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