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Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients

Psoriasis (Ps) is an immune-mediated inflammatory skin disease that is widely associated with the clinical features of metabolic syndrome (MetS), including hypertension, abdominal obesity, insulin resistance, type 2 diabetes and dyslipidemia. Osteopontin (OPN), a multifunctional protein involved in...

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Autores principales: Bartosińska, Joanna, Przepiórka-Kosińska, Joanna, Sarecka-Hujar, Beata, Raczkiewicz, Dorota, Kowal, Małgorzata, Chyl-Surdacka, Katarzyna, Bartosiński, Jarosław, Kosiński, Jakub, Krasowska, Dorota, Chodorowska, Grażyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918436/
https://www.ncbi.nlm.nih.gov/pubmed/33668559
http://dx.doi.org/10.3390/jcm10040755
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author Bartosińska, Joanna
Przepiórka-Kosińska, Joanna
Sarecka-Hujar, Beata
Raczkiewicz, Dorota
Kowal, Małgorzata
Chyl-Surdacka, Katarzyna
Bartosiński, Jarosław
Kosiński, Jakub
Krasowska, Dorota
Chodorowska, Grażyna
author_facet Bartosińska, Joanna
Przepiórka-Kosińska, Joanna
Sarecka-Hujar, Beata
Raczkiewicz, Dorota
Kowal, Małgorzata
Chyl-Surdacka, Katarzyna
Bartosiński, Jarosław
Kosiński, Jakub
Krasowska, Dorota
Chodorowska, Grażyna
author_sort Bartosińska, Joanna
collection PubMed
description Psoriasis (Ps) is an immune-mediated inflammatory skin disease that is widely associated with the clinical features of metabolic syndrome (MetS), including hypertension, abdominal obesity, insulin resistance, type 2 diabetes and dyslipidemia. Osteopontin (OPN), a multifunctional protein involved in the modulation of inflammatory processes, may contribute to the development of atherosclerosis and MetS. Therefore, the aim of the study was the assessment of the correlation between OPN concentration in the peripheral blood and the presence of MetS as well as its particular components in the Ps patients. The study comprised 107 male Ps patients (50 patients with MetS and 57 without MetS) and 38 healthy volunteers (HVs). The concentration of OPN in serum was determined using enzyme-linked immunosorbent assay (ELISA) method. Fasting blood glucose and lipid profile components: total cholesterol (total CHOL), high-density lipoprotein cholesterol (HDL-CHOL), low-density lipoprotein cholesterol (LDL-CHOL), triglycerides (TG) were examined. Ps patients with MetS had significantly higher obesity, systolic blood pressure, TG, CHOL/HDL, LDL/HDL and TG/HDL ratios than Ps patients without MetS. OPN serum concentration was significantly higher in the Ps patients than in the HVs (p = 0.022) but not significantly different between the Ps patients with and without MetS (p = 0.275). OPN serum concentration in Ps patients correlated negatively with total CHOL (p = 0.004) and TG (p = 0.009). OPN is increased in Ps patients and may serve as a biomarker of some lipid abnormalities in them.
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spelling pubmed-79184362021-03-02 Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients Bartosińska, Joanna Przepiórka-Kosińska, Joanna Sarecka-Hujar, Beata Raczkiewicz, Dorota Kowal, Małgorzata Chyl-Surdacka, Katarzyna Bartosiński, Jarosław Kosiński, Jakub Krasowska, Dorota Chodorowska, Grażyna J Clin Med Article Psoriasis (Ps) is an immune-mediated inflammatory skin disease that is widely associated with the clinical features of metabolic syndrome (MetS), including hypertension, abdominal obesity, insulin resistance, type 2 diabetes and dyslipidemia. Osteopontin (OPN), a multifunctional protein involved in the modulation of inflammatory processes, may contribute to the development of atherosclerosis and MetS. Therefore, the aim of the study was the assessment of the correlation between OPN concentration in the peripheral blood and the presence of MetS as well as its particular components in the Ps patients. The study comprised 107 male Ps patients (50 patients with MetS and 57 without MetS) and 38 healthy volunteers (HVs). The concentration of OPN in serum was determined using enzyme-linked immunosorbent assay (ELISA) method. Fasting blood glucose and lipid profile components: total cholesterol (total CHOL), high-density lipoprotein cholesterol (HDL-CHOL), low-density lipoprotein cholesterol (LDL-CHOL), triglycerides (TG) were examined. Ps patients with MetS had significantly higher obesity, systolic blood pressure, TG, CHOL/HDL, LDL/HDL and TG/HDL ratios than Ps patients without MetS. OPN serum concentration was significantly higher in the Ps patients than in the HVs (p = 0.022) but not significantly different between the Ps patients with and without MetS (p = 0.275). OPN serum concentration in Ps patients correlated negatively with total CHOL (p = 0.004) and TG (p = 0.009). OPN is increased in Ps patients and may serve as a biomarker of some lipid abnormalities in them. MDPI 2021-02-13 /pmc/articles/PMC7918436/ /pubmed/33668559 http://dx.doi.org/10.3390/jcm10040755 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bartosińska, Joanna
Przepiórka-Kosińska, Joanna
Sarecka-Hujar, Beata
Raczkiewicz, Dorota
Kowal, Małgorzata
Chyl-Surdacka, Katarzyna
Bartosiński, Jarosław
Kosiński, Jakub
Krasowska, Dorota
Chodorowska, Grażyna
Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients
title Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients
title_full Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients
title_fullStr Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients
title_full_unstemmed Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients
title_short Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients
title_sort osteopontin serum concentration and metabolic syndrome in male psoriatic patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918436/
https://www.ncbi.nlm.nih.gov/pubmed/33668559
http://dx.doi.org/10.3390/jcm10040755
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