Cargando…

Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents

Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of Mycobacterium tuberculosis (Mtb) have developed resistance against most of the established anti-TB drugs, new therapeutic options are urge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mori, Matteo, Stelitano, Giovanni, Chiarelli, Laurent R., Cazzaniga, Giulia, Gelain, Arianna, Barlocco, Daniela, Pini, Elena, Meneghetti, Fiorella, Villa, Stefania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918538/ https://www.ncbi.nlm.nih.gov/pubmed/33668554 http://dx.doi.org/10.3390/ph14020155

Ejemplares similares

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents
por: Chiarelli, Laurent R., et al.
Publicado: (2019)

New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies
por: Pini, Elena, et al.
Publicado: (2018)

Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design
por: Mori, Matteo, et al.
Publicado: (2020)

Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery
por: Mori, Matteo, et al.
Publicado: (2023)

Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections
por: Mori, Matteo, et al.
Publicado: (2022)

Insights on the Modulation of SIRT5 Activity: A Challenging Balance
por: Mori, Matteo, et al.
Publicado: (2022)

Mycobacterium tuberculosis DosR is Required for Activity of the P(mbtB) and P(mbtI) Promoters under Hypoxia
por: Schreuder, Lise J., et al.
Publicado: (2014)

Iron Acquisition and Metabolism as a Promising Target for Antimicrobials (Bottlenecks and Opportunities): Where Do We Stand?
por: Stelitano, Giovanni, et al.
Publicado: (2023)

Targeting Siderophore-Mediated Iron Uptake in M. abscessus: A New Strategy to Limit the Virulence of Non-Tuberculous Mycobacteria
por: Mori, Matteo, et al.
Publicado: (2023)

Special Issue “Novel Antibacterial Agents”
por: Meneghetti, Fiorella, et al.
Publicado: (2021)

Crystal structure of 3-(3-oxo-2,3,4,4a,5,6-hexahydrobenzo[h]cinnolin-2-yl)propionic acid
por: Meneghetti, Fiorella, et al.
Publicado: (2014)

An HTS FP assay able to selectively identify STAT3-DBD inhibitors
por: Meneghetti, Fiorella, et al.
Publicado: (2018)

Special Issue: Frontiers in Antimicrobial Drug Discovery and Design
por: Barlocco, Daniela, et al.
Publicado: (2017)

Towards the Inhibition of Protein–Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives
por: Mori, Matteo, et al.
Publicado: (2020)

치의학전문대학원생의 MBTI 유형과 PBL 학업성취도와의 관계
Publicado: (2014)

Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug
por: Mori, Giorgia, et al.
Publicado: (2020)

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition
por: Capelli, Davide, et al.
Publicado: (2023)

Relationship Between Personality Types in MBTI and Dream Structure Variables
por: Zhao, Chuanwen, et al.
Publicado: (2020)

Exploration of Piperidinols as Potential Antitubercular Agents
por: Abuhammad, Areej, et al.
Publicado: (2014)

MBTI를 활용한 상담프로그램이 일개 의학전문대학원생의 대인관계에 미치는 영향
Publicado: (2011)

Misleading about MBT in Oslo
por: Karterud, Sigmund, et al.
Publicado: (2019)

An Outline of the Latest Crystallographic Studies on Inhibitor-Enzyme Complexes for the Design and Development of New Therapeutics against Tuberculosis
por: Mori, Matteo, et al.
Publicado: (2021)

New Conjugates of Quinoxaline as Potent Antitubercular and Antibacterial Agents
por: Peraman, Ramalingam, et al.
Publicado: (2016)

Predicting judging-perceiving of Myers-Briggs Type Indicator (MBTI) in online social forum
por: Choong, En Jun, et al.
Publicado: (2021)

Phytogenic silver, gold, and bimetallic nanoparticles as novel antitubercular agents
por: Singh, Richa, et al.
Publicado: (2016)

Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity
por: Oliveira, Paulo F. M., et al.
Publicado: (2017)

Improving Protection to Prevent Bacterial Infections: Preliminary Applications of Reverse Vaccinology against the Main Cystic Fibrosis Pathogens
por: Cocorullo, Mario, et al.
Publicado: (2023)

New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling
por: Moodley, Rashmika, et al.
Publicado: (2022)

Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents
por: Kar, Sidhartha S, et al.
Publicado: (2016)

Exploration of 4-aminopyrrolo[2,3-d]pyrimidine as antitubercular agents
por: Jesumoroti, Omobolanle Janet, et al.
Publicado: (2022)

Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis
por: Stelitano, Giovanni, et al.
Publicado: (2020)

Synthesis and Characterization of New Triazole-Bispidinone Scaffolds and Their Metal Complexes for Catalytic Applications
por: Rossetti, Arianna, et al.
Publicado: (2023)

Les types de personnalité MBTI et CCTI: se connaître pour construire des relations harmonieuses
por: Cauvin, Pierre, et al.
Publicado: (2019)

Comment utiliser le MBTI: les 16 types de personnalité pour savoir qui vous êtes
por: Fléron, Benjamin
Publicado: (2015)

Change of acknowledgments in “The relationship between dental graduate students’ MBTI types and academic achievement in problem-based learning„
Publicado: (2015)

Synthesis, In Vitro Screening and Docking Studies of New Thiosemicarbazide Derivatives as Antitubercular Agents
por: Pitucha, Monika, et al.
Publicado: (2019)

Cinnamic Derivatives as Antitubercular Agents: Characterization by Quantitative Structure–Activity Relationship Studies
por: Teixeira, Cátia, et al.
Publicado: (2020)

Papulonecrotic tuberculid caused by Bacille Calmette-Guerin vaccination requiring no antitubercular agents
por: Araki, Kotaro, et al.
Publicado: (2020)

Comparison of the Efficacy of Two Novel Antitubercular Agents in Free and Liposome-Encapsulated Formulations
por: Kósa, Nikoletta, et al.
Publicado: (2021)

Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones
por: Polaquini, Carlos R., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_o2janaairs49qusnp54uu49rsn