Cargando…

Novel Regulators of the IGF System in Cancer

The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metab...

Descripción completa

Detalles Bibliográficos
Autores principales: Mancarella, Caterina, Morrione, Andrea, Scotlandi, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918569/
https://www.ncbi.nlm.nih.gov/pubmed/33673232
http://dx.doi.org/10.3390/biom11020273
_version_ 1783657953040007168
author Mancarella, Caterina
Morrione, Andrea
Scotlandi, Katia
author_facet Mancarella, Caterina
Morrione, Andrea
Scotlandi, Katia
author_sort Mancarella, Caterina
collection PubMed
description The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia.
format Online
Article
Text
id pubmed-7918569
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79185692021-03-02 Novel Regulators of the IGF System in Cancer Mancarella, Caterina Morrione, Andrea Scotlandi, Katia Biomolecules Review The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia. MDPI 2021-02-12 /pmc/articles/PMC7918569/ /pubmed/33673232 http://dx.doi.org/10.3390/biom11020273 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mancarella, Caterina
Morrione, Andrea
Scotlandi, Katia
Novel Regulators of the IGF System in Cancer
title Novel Regulators of the IGF System in Cancer
title_full Novel Regulators of the IGF System in Cancer
title_fullStr Novel Regulators of the IGF System in Cancer
title_full_unstemmed Novel Regulators of the IGF System in Cancer
title_short Novel Regulators of the IGF System in Cancer
title_sort novel regulators of the igf system in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918569/
https://www.ncbi.nlm.nih.gov/pubmed/33673232
http://dx.doi.org/10.3390/biom11020273
work_keys_str_mv AT mancarellacaterina novelregulatorsoftheigfsystemincancer
AT morrioneandrea novelregulatorsoftheigfsystemincancer
AT scotlandikatia novelregulatorsoftheigfsystemincancer