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Novel Regulators of the IGF System in Cancer
The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metab...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918569/ https://www.ncbi.nlm.nih.gov/pubmed/33673232 http://dx.doi.org/10.3390/biom11020273 |
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author | Mancarella, Caterina Morrione, Andrea Scotlandi, Katia |
author_facet | Mancarella, Caterina Morrione, Andrea Scotlandi, Katia |
author_sort | Mancarella, Caterina |
collection | PubMed |
description | The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia. |
format | Online Article Text |
id | pubmed-7918569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79185692021-03-02 Novel Regulators of the IGF System in Cancer Mancarella, Caterina Morrione, Andrea Scotlandi, Katia Biomolecules Review The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia. MDPI 2021-02-12 /pmc/articles/PMC7918569/ /pubmed/33673232 http://dx.doi.org/10.3390/biom11020273 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mancarella, Caterina Morrione, Andrea Scotlandi, Katia Novel Regulators of the IGF System in Cancer |
title | Novel Regulators of the IGF System in Cancer |
title_full | Novel Regulators of the IGF System in Cancer |
title_fullStr | Novel Regulators of the IGF System in Cancer |
title_full_unstemmed | Novel Regulators of the IGF System in Cancer |
title_short | Novel Regulators of the IGF System in Cancer |
title_sort | novel regulators of the igf system in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918569/ https://www.ncbi.nlm.nih.gov/pubmed/33673232 http://dx.doi.org/10.3390/biom11020273 |
work_keys_str_mv | AT mancarellacaterina novelregulatorsoftheigfsystemincancer AT morrioneandrea novelregulatorsoftheigfsystemincancer AT scotlandikatia novelregulatorsoftheigfsystemincancer |