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Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence
Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems, mainly in brain regions involved in the neurobiology of anxiety and depression. 5-HT receptors are currently promising targets for discovering new drugs for treating disorders ranging from migraine to neuropsychi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918669/ https://www.ncbi.nlm.nih.gov/pubmed/33673205 http://dx.doi.org/10.3390/ph14020148 |
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author | Villas-Boas, Gustavo R. Lavorato, Stefânia N. Paes, Marina M. de Carvalho, Pablinny M. G. Rescia, Vanessa C. Cunha, Mila S. de Magalhães-Filho, Manoel F. Ponsoni, Luis F. de Carvalho, Adryano Augustto Valladao de Lacerda, Roseli B. da S. Leite, Lais da S. Tavares-Henriques, Matheus Lopes, Luiz A. F. Oliveira, Luiz G. R. Silva-Filho, Saulo E. da Silveira, Ana P. S. Cuman, Roberto K. N. de S. Silva-Comar, Francielli M. Comar, Jurandir F. do A. Brasileiro, Luana dos Santos, Jussileide N. de Freitas, William R. Leão, Katyuscya V. da Silva, Jonatas G. Klein, Raphael C. Klein, Mary H. F. da S. Ramos, Bruno H. Fernandes, Cristiane K. C. de L. Ribas, Dayane G. Oesterreich, Silvia A. |
author_facet | Villas-Boas, Gustavo R. Lavorato, Stefânia N. Paes, Marina M. de Carvalho, Pablinny M. G. Rescia, Vanessa C. Cunha, Mila S. de Magalhães-Filho, Manoel F. Ponsoni, Luis F. de Carvalho, Adryano Augustto Valladao de Lacerda, Roseli B. da S. Leite, Lais da S. Tavares-Henriques, Matheus Lopes, Luiz A. F. Oliveira, Luiz G. R. Silva-Filho, Saulo E. da Silveira, Ana P. S. Cuman, Roberto K. N. de S. Silva-Comar, Francielli M. Comar, Jurandir F. do A. Brasileiro, Luana dos Santos, Jussileide N. de Freitas, William R. Leão, Katyuscya V. da Silva, Jonatas G. Klein, Raphael C. Klein, Mary H. F. da S. Ramos, Bruno H. Fernandes, Cristiane K. C. de L. Ribas, Dayane G. Oesterreich, Silvia A. |
author_sort | Villas-Boas, Gustavo R. |
collection | PubMed |
description | Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems, mainly in brain regions involved in the neurobiology of anxiety and depression. 5-HT receptors are currently promising targets for discovering new drugs for treating disorders ranging from migraine to neuropsychiatric upsets, such as anxiety and depression. It is well described in the current literature that the brain expresses seven types of 5-HT receptors comprising eighteen distinct subtypes. In this article, we comprehensively reviewed 5-HT1-7 receptors. Of the eighteen 5-HT receptors known today, thirteen are G protein-coupled receptors (GPCRs) and represent targets for approximately 40% of drugs used in humans. Signaling pathways related to these receptors play a crucial role in neurodevelopment and can be modulated to develop effective therapies to treat anxiety and depression. This review presents the experimental evidence of the modulation of the “serotonergic receptosome” in the treatment of anxiety and depression, as well as demonstrating state-of-the-art research related to phytochemicals and these disorders. In addition, detailed aspects of the pharmacological mechanism of action of all currently known 5-HT receptor families were reviewed. From this review, it will be possible to direct the rational design of drugs towards new therapies that involve signaling via 5-HT receptors. |
format | Online Article Text |
id | pubmed-7918669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79186692021-03-02 Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence Villas-Boas, Gustavo R. Lavorato, Stefânia N. Paes, Marina M. de Carvalho, Pablinny M. G. Rescia, Vanessa C. Cunha, Mila S. de Magalhães-Filho, Manoel F. Ponsoni, Luis F. de Carvalho, Adryano Augustto Valladao de Lacerda, Roseli B. da S. Leite, Lais da S. Tavares-Henriques, Matheus Lopes, Luiz A. F. Oliveira, Luiz G. R. Silva-Filho, Saulo E. da Silveira, Ana P. S. Cuman, Roberto K. N. de S. Silva-Comar, Francielli M. Comar, Jurandir F. do A. Brasileiro, Luana dos Santos, Jussileide N. de Freitas, William R. Leão, Katyuscya V. da Silva, Jonatas G. Klein, Raphael C. Klein, Mary H. F. da S. Ramos, Bruno H. Fernandes, Cristiane K. C. de L. Ribas, Dayane G. Oesterreich, Silvia A. Pharmaceuticals (Basel) Review Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems, mainly in brain regions involved in the neurobiology of anxiety and depression. 5-HT receptors are currently promising targets for discovering new drugs for treating disorders ranging from migraine to neuropsychiatric upsets, such as anxiety and depression. It is well described in the current literature that the brain expresses seven types of 5-HT receptors comprising eighteen distinct subtypes. In this article, we comprehensively reviewed 5-HT1-7 receptors. Of the eighteen 5-HT receptors known today, thirteen are G protein-coupled receptors (GPCRs) and represent targets for approximately 40% of drugs used in humans. Signaling pathways related to these receptors play a crucial role in neurodevelopment and can be modulated to develop effective therapies to treat anxiety and depression. This review presents the experimental evidence of the modulation of the “serotonergic receptosome” in the treatment of anxiety and depression, as well as demonstrating state-of-the-art research related to phytochemicals and these disorders. In addition, detailed aspects of the pharmacological mechanism of action of all currently known 5-HT receptor families were reviewed. From this review, it will be possible to direct the rational design of drugs towards new therapies that involve signaling via 5-HT receptors. MDPI 2021-02-12 /pmc/articles/PMC7918669/ /pubmed/33673205 http://dx.doi.org/10.3390/ph14020148 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Villas-Boas, Gustavo R. Lavorato, Stefânia N. Paes, Marina M. de Carvalho, Pablinny M. G. Rescia, Vanessa C. Cunha, Mila S. de Magalhães-Filho, Manoel F. Ponsoni, Luis F. de Carvalho, Adryano Augustto Valladao de Lacerda, Roseli B. da S. Leite, Lais da S. Tavares-Henriques, Matheus Lopes, Luiz A. F. Oliveira, Luiz G. R. Silva-Filho, Saulo E. da Silveira, Ana P. S. Cuman, Roberto K. N. de S. Silva-Comar, Francielli M. Comar, Jurandir F. do A. Brasileiro, Luana dos Santos, Jussileide N. de Freitas, William R. Leão, Katyuscya V. da Silva, Jonatas G. Klein, Raphael C. Klein, Mary H. F. da S. Ramos, Bruno H. Fernandes, Cristiane K. C. de L. Ribas, Dayane G. Oesterreich, Silvia A. Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence |
title | Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence |
title_full | Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence |
title_fullStr | Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence |
title_full_unstemmed | Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence |
title_short | Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence |
title_sort | modulation of the serotonergic receptosome in the treatment of anxiety and depression: a narrative review of the experimental evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918669/ https://www.ncbi.nlm.nih.gov/pubmed/33673205 http://dx.doi.org/10.3390/ph14020148 |
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