Cargando…

AKT3 Expression in Mesenchymal Colorectal Cancer Cells Drives Growth and Is Associated with Epithelial-Mesenchymal Transition

SIMPLE SUMMARY: Colorectal cancer can be subdivided into four distinct subtypes that are characterised by different clinical features and responses to therapies currently used in the clinic to treat this disease. One of those subtypes, called CMS4, is associated with a worse prognosis and poor respo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buikhuisen, Joyce Y., Gomez Barila, Patricia M., Torang, Arezo, Dekker, Daniëlle, de Jong, Joan H., Cameron, Kate, Vitale, Sara, Stassi, Giorgio, van Hooff, Sander R., Castro, Mauro A. A., Vermeulen, Louis, Medema, Jan Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918753/ https://www.ncbi.nlm.nih.gov/pubmed/33673003 http://dx.doi.org/10.3390/cancers13040801

Ejemplares similares

Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
por: Buikhuisen, Joyce Y., et al.
Publicado: (2023)

Exploring and modelling colon cancer inter-tumour heterogeneity: opportunities and challenges
por: Buikhuisen, Joyce Y., et al.
Publicado: (2020)

An Unsupervised Strategy for Identifying Epithelial-Mesenchymal Transition State Metrics in Breast Cancer and Melanoma
por: Klinke, David J., et al.
Publicado: (2020)

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype
por: Fessler, Evelyn, et al.
Publicado: (2016)

A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype
por: Fessler, E, et al.
Publicado: (2016)

An elastic-net logistic regression approach to generate classifiers and gene signatures for types of immune cells and T helper cell subsets
por: Torang, Arezo, et al.
Publicado: (2019)

Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype
por: Di Franco, Simone, et al.
Publicado: (2021)

Development of a miRNA‐based classifier for detection of colorectal cancer molecular subtypes
por: Adam, Ronja S., et al.
Publicado: (2022)

Protein kinase B/AKT isoform 2 drives migration of human mesenchymal stem cells
por: BULJ, ZRINKA, et al.
Publicado: (2012)

Akt promotes Endocardial-Mesenchyme Transition
por: Meadows, Kafi N, et al.
Publicado: (2009)

Capturing colorectal cancer inter‐tumor heterogeneity in patient‐derived xenograft (PDX) models
por: Prasetyanti, Pramudita R., et al.
Publicado: (2018)

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition
por: Irie, Hanna Y., et al.
Publicado: (2005)

AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer
por: Varga, Julia, et al.
Publicado: (2020)

High‐grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF‐1
por: Steins, Anne, et al.
Publicado: (2020)

Kinase-targeted therapy in subsets of colorectal cancer
por: Gomez Barila, Patricia M., et al.
Publicado: (2023)

Expression of the FGFR2 mesenchymal splicing variant in epithelial cells drives epithelial-mesenchymal transition
por: Ranieri, Danilo, et al.
Publicado: (2015)

Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases
por: Margarido, Andreia S., et al.
Publicado: (2022)

Bone Marrow-Derived Mesenchymal Cell Differentiation toward Myogenic Lineages: Facts and Perspectives
por: Galli, Daniela, et al.
Publicado: (2014)

Dysregulated mesenchymal PDGFR‐β drives kidney fibrosis
por: Buhl, Eva M, et al.
Publicado: (2020)

Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma
por: Ebbing, Eva A., et al.
Publicado: (2019)

Microenvironment in neuroblastoma: isolation and characterization of tumor-derived mesenchymal stromal cells
por: Pelizzo, Gloria, et al.
Publicado: (2018)

ZKSCAN3 drives tumor metastasis via integrin β4/FAK/AKT mediated epithelial–mesenchymal transition in hepatocellular carcinoma
por: Li, Jieqiong, et al.
Publicado: (2020)

Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems
por: Dijk, Frederike, et al.
Publicado: (2020)

Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis
por: Fan, Huihui, et al.
Publicado: (2020)

Interleukin-8 drives epithelial-mesenchymal transition of human carcinomas
por: Fernando, Romaine I, et al.
Publicado: (2013)

Bone Marrow-Derived Mesenchymal Stem Cells Drive Lymphangiogenesis
por: Maertens, Ludovic, et al.
Publicado: (2014)

Endothelin‐1 Drives Epithelial‐Mesenchymal Transition in Hypertensive Nephroangiosclerosis
por: Seccia, Teresa M., et al.
Publicado: (2016)

ERK signalling modulates epigenome to drive epithelial to mesenchymal transition
por: Navandar, Mohit, et al.
Publicado: (2017)

FACS-based protocol to assess cytotoxicity and clonogenic potential of colorectal cancer stem cells using a Wnt/β-catenin signaling pathway reporter
por: Di Franco, Simone, et al.
Publicado: (2021)

Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells
por: Nonpanya, Nongyao, et al.
Publicado: (2021)

Critical roles of TLRs on the polarization of mesenchymal stem cells for cell therapy of viral infections: a notice for COVID-19 treatment
por: Gholizadeh-Ghaleh Aziz, Shiva, et al.
Publicado: (2021)

Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling
por: Ray, Poulomi, et al.
Publicado: (2015)

Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth
por: Haldipur, Parthiv, et al.
Publicado: (2014)

Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells
por: Vidoni, Chiara, et al.
Publicado: (2019)

Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition
por: Quaresma, Margarida C., et al.
Publicado: (2020)

New Actors Driving the Epithelial–Mesenchymal Transition in Cancer: The Role of Leptin
por: Olea-Flores, Monserrat, et al.
Publicado: (2020)

Driving mesenchymal stem cell differentiation from self-assembled monolayers
por: Tew, L. S., et al.
Publicado: (2018)

Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence
por: Rastaldo, Raffaella, et al.
Publicado: (2020)

Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma
por: Sa, Jason K., et al.
Publicado: (2020)

Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis
por: Strippoli, Raffaele, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3ffnrfekqvekn4eokl4l86qhb2