TRPA1: An asthma target with a zing

Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel in...

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Detalles Bibliográficos
Autor principal: Jordt, Sven-Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918757/
https://www.ncbi.nlm.nih.gov/pubmed/33625497
http://dx.doi.org/10.1084/jem.20202507
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author Jordt, Sven-Eric
author_facet Jordt, Sven-Eric
author_sort Jordt, Sven-Eric
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description Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel inhibitor of TRPA1, a nerve receptor for irritants and reactive endogenous mediators, suppresses inflammation and airway smooth muscle contraction in several preclinical species.
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spelling pubmed-79187572021-10-05 TRPA1: An asthma target with a zing Jordt, Sven-Eric J Exp Med Insights Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel inhibitor of TRPA1, a nerve receptor for irritants and reactive endogenous mediators, suppresses inflammation and airway smooth muscle contraction in several preclinical species. Rockefeller University Press 2021-02-24 /pmc/articles/PMC7918757/ /pubmed/33625497 http://dx.doi.org/10.1084/jem.20202507 Text en © 2021 Jordt http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Jordt, Sven-Eric
TRPA1: An asthma target with a zing
title TRPA1: An asthma target with a zing
title_full TRPA1: An asthma target with a zing
title_fullStr TRPA1: An asthma target with a zing
title_full_unstemmed TRPA1: An asthma target with a zing
title_short TRPA1: An asthma target with a zing
title_sort trpa1: an asthma target with a zing
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918757/
https://www.ncbi.nlm.nih.gov/pubmed/33625497
http://dx.doi.org/10.1084/jem.20202507
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