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Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production
Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918762/ https://www.ncbi.nlm.nih.gov/pubmed/33670275 http://dx.doi.org/10.3390/ijerph18041758 |
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author | Iftikhar, Mehwish Noureen, Aasma Uzair, Muhammad Jabeen, Farhat Abdel Daim, Mohamed Cappello, Tiziana |
author_facet | Iftikhar, Mehwish Noureen, Aasma Uzair, Muhammad Jabeen, Farhat Abdel Daim, Mohamed Cappello, Tiziana |
author_sort | Iftikhar, Mehwish |
collection | PubMed |
description | Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different primary and secondary organs but few studies have focused on NPs’ deposition in reproductive organs. Noteworthy, even fewer studies have dealt with the toxic effects of NPs on reproductive indices and sperm parameters (such as sperm number, motility and morphology) by evaluating, for instance, the histopathology of seminiferous tubules and testosterone levels. To date, the research suggests that NPs can easily cross the blood testes barrier and, after accumulation in the testis, induce adverse effects on spermatogenesis. This review aims to summarize the available literature on the risks induced by NPs on the male reproductive system. |
format | Online Article Text |
id | pubmed-7918762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79187622021-03-02 Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production Iftikhar, Mehwish Noureen, Aasma Uzair, Muhammad Jabeen, Farhat Abdel Daim, Mohamed Cappello, Tiziana Int J Environ Res Public Health Review Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different primary and secondary organs but few studies have focused on NPs’ deposition in reproductive organs. Noteworthy, even fewer studies have dealt with the toxic effects of NPs on reproductive indices and sperm parameters (such as sperm number, motility and morphology) by evaluating, for instance, the histopathology of seminiferous tubules and testosterone levels. To date, the research suggests that NPs can easily cross the blood testes barrier and, after accumulation in the testis, induce adverse effects on spermatogenesis. This review aims to summarize the available literature on the risks induced by NPs on the male reproductive system. MDPI 2021-02-11 2021-02 /pmc/articles/PMC7918762/ /pubmed/33670275 http://dx.doi.org/10.3390/ijerph18041758 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Iftikhar, Mehwish Noureen, Aasma Uzair, Muhammad Jabeen, Farhat Abdel Daim, Mohamed Cappello, Tiziana Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production |
title | Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production |
title_full | Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production |
title_fullStr | Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production |
title_full_unstemmed | Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production |
title_short | Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production |
title_sort | perspectives of nanoparticles in male infertility: evidence for induced abnormalities in sperm production |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918762/ https://www.ncbi.nlm.nih.gov/pubmed/33670275 http://dx.doi.org/10.3390/ijerph18041758 |
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