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Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production

Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different...

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Detalles Bibliográficos
Autores principales: Iftikhar, Mehwish, Noureen, Aasma, Uzair, Muhammad, Jabeen, Farhat, Abdel Daim, Mohamed, Cappello, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918762/
https://www.ncbi.nlm.nih.gov/pubmed/33670275
http://dx.doi.org/10.3390/ijerph18041758
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author Iftikhar, Mehwish
Noureen, Aasma
Uzair, Muhammad
Jabeen, Farhat
Abdel Daim, Mohamed
Cappello, Tiziana
author_facet Iftikhar, Mehwish
Noureen, Aasma
Uzair, Muhammad
Jabeen, Farhat
Abdel Daim, Mohamed
Cappello, Tiziana
author_sort Iftikhar, Mehwish
collection PubMed
description Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different primary and secondary organs but few studies have focused on NPs’ deposition in reproductive organs. Noteworthy, even fewer studies have dealt with the toxic effects of NPs on reproductive indices and sperm parameters (such as sperm number, motility and morphology) by evaluating, for instance, the histopathology of seminiferous tubules and testosterone levels. To date, the research suggests that NPs can easily cross the blood testes barrier and, after accumulation in the testis, induce adverse effects on spermatogenesis. This review aims to summarize the available literature on the risks induced by NPs on the male reproductive system.
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spelling pubmed-79187622021-03-02 Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production Iftikhar, Mehwish Noureen, Aasma Uzair, Muhammad Jabeen, Farhat Abdel Daim, Mohamed Cappello, Tiziana Int J Environ Res Public Health Review Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different primary and secondary organs but few studies have focused on NPs’ deposition in reproductive organs. Noteworthy, even fewer studies have dealt with the toxic effects of NPs on reproductive indices and sperm parameters (such as sperm number, motility and morphology) by evaluating, for instance, the histopathology of seminiferous tubules and testosterone levels. To date, the research suggests that NPs can easily cross the blood testes barrier and, after accumulation in the testis, induce adverse effects on spermatogenesis. This review aims to summarize the available literature on the risks induced by NPs on the male reproductive system. MDPI 2021-02-11 2021-02 /pmc/articles/PMC7918762/ /pubmed/33670275 http://dx.doi.org/10.3390/ijerph18041758 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Iftikhar, Mehwish
Noureen, Aasma
Uzair, Muhammad
Jabeen, Farhat
Abdel Daim, Mohamed
Cappello, Tiziana
Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production
title Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production
title_full Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production
title_fullStr Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production
title_full_unstemmed Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production
title_short Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production
title_sort perspectives of nanoparticles in male infertility: evidence for induced abnormalities in sperm production
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918762/
https://www.ncbi.nlm.nih.gov/pubmed/33670275
http://dx.doi.org/10.3390/ijerph18041758
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