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Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study

Background: In this study, we investigated the effectiveness of FreeStyle Libre Flash Glucose Monitoring (FGM) implementation in a real life clinical setting with the emphasis on the effect of initial education on the use of the FGM system. Methods: This prospective observational study included 425...

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Autores principales: Canecki Varzic, Silvija, Steiner, Kristina, Gradinjan Centner, Maja, Grgurevic, Mladen, Cigrovski Berkovic, Maja, Klobucar Majanovic, Sanja, Radman, Maja, Milicevic, Tanja, Rahelic, Dario, Bilic Curcic, Ines
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918764/
https://www.ncbi.nlm.nih.gov/pubmed/33668675
http://dx.doi.org/10.3390/diagnostics11020305
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author Canecki Varzic, Silvija
Steiner, Kristina
Gradinjan Centner, Maja
Grgurevic, Mladen
Cigrovski Berkovic, Maja
Klobucar Majanovic, Sanja
Radman, Maja
Milicevic, Tanja
Rahelic, Dario
Bilic Curcic, Ines
author_facet Canecki Varzic, Silvija
Steiner, Kristina
Gradinjan Centner, Maja
Grgurevic, Mladen
Cigrovski Berkovic, Maja
Klobucar Majanovic, Sanja
Radman, Maja
Milicevic, Tanja
Rahelic, Dario
Bilic Curcic, Ines
author_sort Canecki Varzic, Silvija
collection PubMed
description Background: In this study, we investigated the effectiveness of FreeStyle Libre Flash Glucose Monitoring (FGM) implementation in a real life clinical setting with the emphasis on the effect of initial education on the use of the FGM system. Methods: This prospective observational study included 425 diabetes type 1 subjects followed up for 3 to 12 months (320 were followed up to 3 months, 267 up to 6 months and 147 up to period of one year). An FGM sensor was placed at study entry and all participants were educated through a period of 5 days on sensor usage and self-management of glycemia with follow up visits every 3 months. Results: HbA1c values significantly decreased from baseline (T0) to 3 months (T3) (p < 0.001), with a drop from 7.48% ± 0.1% to 7.30 ± 0.1%. There was no change in time spent in hypoglycemia from T3 to T12, although there was a decreasing trend present. The change in HbA1c values in the entire cohort was driven by change in the subgroup of patients with HbA1c ≥7% with a drop from 8.22% ± 1.14% to 7.68% ± 1.26% (p < 0.0001) in the first 3 months. Also, in individuals performing SMBG less than 5 times per day, there was a steady decrease in HbA1c levels up to 6 months (p < 0.05 and p < 0.001, respectively) as opposed to those who performed SMBG ≥5 times per day. Conclusions: The improvement in HbA1c was mainly driven by the increase in the number of scans per day. The subjects with poorer glycemic control and those who seldom performed SMBG benefited the most.
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spelling pubmed-79187642021-03-02 Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study Canecki Varzic, Silvija Steiner, Kristina Gradinjan Centner, Maja Grgurevic, Mladen Cigrovski Berkovic, Maja Klobucar Majanovic, Sanja Radman, Maja Milicevic, Tanja Rahelic, Dario Bilic Curcic, Ines Diagnostics (Basel) Article Background: In this study, we investigated the effectiveness of FreeStyle Libre Flash Glucose Monitoring (FGM) implementation in a real life clinical setting with the emphasis on the effect of initial education on the use of the FGM system. Methods: This prospective observational study included 425 diabetes type 1 subjects followed up for 3 to 12 months (320 were followed up to 3 months, 267 up to 6 months and 147 up to period of one year). An FGM sensor was placed at study entry and all participants were educated through a period of 5 days on sensor usage and self-management of glycemia with follow up visits every 3 months. Results: HbA1c values significantly decreased from baseline (T0) to 3 months (T3) (p < 0.001), with a drop from 7.48% ± 0.1% to 7.30 ± 0.1%. There was no change in time spent in hypoglycemia from T3 to T12, although there was a decreasing trend present. The change in HbA1c values in the entire cohort was driven by change in the subgroup of patients with HbA1c ≥7% with a drop from 8.22% ± 1.14% to 7.68% ± 1.26% (p < 0.0001) in the first 3 months. Also, in individuals performing SMBG less than 5 times per day, there was a steady decrease in HbA1c levels up to 6 months (p < 0.05 and p < 0.001, respectively) as opposed to those who performed SMBG ≥5 times per day. Conclusions: The improvement in HbA1c was mainly driven by the increase in the number of scans per day. The subjects with poorer glycemic control and those who seldom performed SMBG benefited the most. MDPI 2021-02-13 /pmc/articles/PMC7918764/ /pubmed/33668675 http://dx.doi.org/10.3390/diagnostics11020305 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Canecki Varzic, Silvija
Steiner, Kristina
Gradinjan Centner, Maja
Grgurevic, Mladen
Cigrovski Berkovic, Maja
Klobucar Majanovic, Sanja
Radman, Maja
Milicevic, Tanja
Rahelic, Dario
Bilic Curcic, Ines
Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study
title Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study
title_full Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study
title_fullStr Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study
title_full_unstemmed Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study
title_short Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study
title_sort assessment of freestyle libre flash glucose monitoring system implementation in real life clinical setting: a prospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918764/
https://www.ncbi.nlm.nih.gov/pubmed/33668675
http://dx.doi.org/10.3390/diagnostics11020305
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