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Summary of Guidelines for Managing Histoplasmosis among People Living with HIV

Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population. In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was publ...

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Autores principales: Perez, Freddy, Caceres, Diego H., Ford, Nathan, Ravasi, Giovanni, Gomez, Beatriz L., Pasqualotto, Alessandro C., Hine, Paul, Adenis, Antoine A., Nacher, Mathieu, Chiller, Tom, Baddley, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918769/
https://www.ncbi.nlm.nih.gov/pubmed/33673384
http://dx.doi.org/10.3390/jof7020134
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author Perez, Freddy
Caceres, Diego H.
Ford, Nathan
Ravasi, Giovanni
Gomez, Beatriz L.
Pasqualotto, Alessandro C.
Hine, Paul
Adenis, Antoine A.
Nacher, Mathieu
Chiller, Tom
Baddley, John
author_facet Perez, Freddy
Caceres, Diego H.
Ford, Nathan
Ravasi, Giovanni
Gomez, Beatriz L.
Pasqualotto, Alessandro C.
Hine, Paul
Adenis, Antoine A.
Nacher, Mathieu
Chiller, Tom
Baddley, John
author_sort Perez, Freddy
collection PubMed
description Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population. In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was published. This document recommends (1) detection of circulating Histoplasma antigens as the recommended laboratory assay to diagnose histoplasmosis among PLHIV; (2) the use of liposomal amphotericin for induction therapy in severe or moderately severe disease, followed by a maintenance therapy with itraconazole for 12 months; a shorter maintenance therapy could be considered if the patient is clinically stable and if immune status has improved; (3) antiretroviral therapy initiation as soon as possible among patients with histoplasmosis without involvement of central nervous system; and (4) that for the treatment of co-infection with histoplasmosis and tuberculosis (TB), treatment of TB should be initiated according to the World Health Organization treatment guidelines. Appropriate health education of providers, supportive supervision, and policy guidance for the care of PLHIV are required.
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spelling pubmed-79187692021-03-02 Summary of Guidelines for Managing Histoplasmosis among People Living with HIV Perez, Freddy Caceres, Diego H. Ford, Nathan Ravasi, Giovanni Gomez, Beatriz L. Pasqualotto, Alessandro C. Hine, Paul Adenis, Antoine A. Nacher, Mathieu Chiller, Tom Baddley, John J Fungi (Basel) Communication Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population. In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was published. This document recommends (1) detection of circulating Histoplasma antigens as the recommended laboratory assay to diagnose histoplasmosis among PLHIV; (2) the use of liposomal amphotericin for induction therapy in severe or moderately severe disease, followed by a maintenance therapy with itraconazole for 12 months; a shorter maintenance therapy could be considered if the patient is clinically stable and if immune status has improved; (3) antiretroviral therapy initiation as soon as possible among patients with histoplasmosis without involvement of central nervous system; and (4) that for the treatment of co-infection with histoplasmosis and tuberculosis (TB), treatment of TB should be initiated according to the World Health Organization treatment guidelines. Appropriate health education of providers, supportive supervision, and policy guidance for the care of PLHIV are required. MDPI 2021-02-12 /pmc/articles/PMC7918769/ /pubmed/33673384 http://dx.doi.org/10.3390/jof7020134 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Perez, Freddy
Caceres, Diego H.
Ford, Nathan
Ravasi, Giovanni
Gomez, Beatriz L.
Pasqualotto, Alessandro C.
Hine, Paul
Adenis, Antoine A.
Nacher, Mathieu
Chiller, Tom
Baddley, John
Summary of Guidelines for Managing Histoplasmosis among People Living with HIV
title Summary of Guidelines for Managing Histoplasmosis among People Living with HIV
title_full Summary of Guidelines for Managing Histoplasmosis among People Living with HIV
title_fullStr Summary of Guidelines for Managing Histoplasmosis among People Living with HIV
title_full_unstemmed Summary of Guidelines for Managing Histoplasmosis among People Living with HIV
title_short Summary of Guidelines for Managing Histoplasmosis among People Living with HIV
title_sort summary of guidelines for managing histoplasmosis among people living with hiv
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918769/
https://www.ncbi.nlm.nih.gov/pubmed/33673384
http://dx.doi.org/10.3390/jof7020134
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