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Summary of Guidelines for Managing Histoplasmosis among People Living with HIV
Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population. In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was publ...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918769/ https://www.ncbi.nlm.nih.gov/pubmed/33673384 http://dx.doi.org/10.3390/jof7020134 |
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author | Perez, Freddy Caceres, Diego H. Ford, Nathan Ravasi, Giovanni Gomez, Beatriz L. Pasqualotto, Alessandro C. Hine, Paul Adenis, Antoine A. Nacher, Mathieu Chiller, Tom Baddley, John |
author_facet | Perez, Freddy Caceres, Diego H. Ford, Nathan Ravasi, Giovanni Gomez, Beatriz L. Pasqualotto, Alessandro C. Hine, Paul Adenis, Antoine A. Nacher, Mathieu Chiller, Tom Baddley, John |
author_sort | Perez, Freddy |
collection | PubMed |
description | Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population. In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was published. This document recommends (1) detection of circulating Histoplasma antigens as the recommended laboratory assay to diagnose histoplasmosis among PLHIV; (2) the use of liposomal amphotericin for induction therapy in severe or moderately severe disease, followed by a maintenance therapy with itraconazole for 12 months; a shorter maintenance therapy could be considered if the patient is clinically stable and if immune status has improved; (3) antiretroviral therapy initiation as soon as possible among patients with histoplasmosis without involvement of central nervous system; and (4) that for the treatment of co-infection with histoplasmosis and tuberculosis (TB), treatment of TB should be initiated according to the World Health Organization treatment guidelines. Appropriate health education of providers, supportive supervision, and policy guidance for the care of PLHIV are required. |
format | Online Article Text |
id | pubmed-7918769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79187692021-03-02 Summary of Guidelines for Managing Histoplasmosis among People Living with HIV Perez, Freddy Caceres, Diego H. Ford, Nathan Ravasi, Giovanni Gomez, Beatriz L. Pasqualotto, Alessandro C. Hine, Paul Adenis, Antoine A. Nacher, Mathieu Chiller, Tom Baddley, John J Fungi (Basel) Communication Histoplasmosis is a frequent fungal opportunistic infection in people living with HIV (PLHIV), associated every year to a total of 5% to 15% of AIDS-related deaths among this population. In 2020, the first global guidelines for diagnosing and managing disseminated histoplasmosis among PLHIV was published. This document recommends (1) detection of circulating Histoplasma antigens as the recommended laboratory assay to diagnose histoplasmosis among PLHIV; (2) the use of liposomal amphotericin for induction therapy in severe or moderately severe disease, followed by a maintenance therapy with itraconazole for 12 months; a shorter maintenance therapy could be considered if the patient is clinically stable and if immune status has improved; (3) antiretroviral therapy initiation as soon as possible among patients with histoplasmosis without involvement of central nervous system; and (4) that for the treatment of co-infection with histoplasmosis and tuberculosis (TB), treatment of TB should be initiated according to the World Health Organization treatment guidelines. Appropriate health education of providers, supportive supervision, and policy guidance for the care of PLHIV are required. MDPI 2021-02-12 /pmc/articles/PMC7918769/ /pubmed/33673384 http://dx.doi.org/10.3390/jof7020134 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Perez, Freddy Caceres, Diego H. Ford, Nathan Ravasi, Giovanni Gomez, Beatriz L. Pasqualotto, Alessandro C. Hine, Paul Adenis, Antoine A. Nacher, Mathieu Chiller, Tom Baddley, John Summary of Guidelines for Managing Histoplasmosis among People Living with HIV |
title | Summary of Guidelines for Managing Histoplasmosis among People Living with HIV |
title_full | Summary of Guidelines for Managing Histoplasmosis among People Living with HIV |
title_fullStr | Summary of Guidelines for Managing Histoplasmosis among People Living with HIV |
title_full_unstemmed | Summary of Guidelines for Managing Histoplasmosis among People Living with HIV |
title_short | Summary of Guidelines for Managing Histoplasmosis among People Living with HIV |
title_sort | summary of guidelines for managing histoplasmosis among people living with hiv |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918769/ https://www.ncbi.nlm.nih.gov/pubmed/33673384 http://dx.doi.org/10.3390/jof7020134 |
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