Cargando…

Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome

In a cohort of 190,599 participants from The National Health Insurance Service-National Health Screening (NHIS-HEALS) study, we investigated the association of changes in the predicted body composition and metabolic profiles with the risk of metabolic syndrome (MetS) in the general population, which...

Descripción completa

Detalles Bibliográficos
Autores principales: Oh, Yun Hwan, Choi, Seulggie, Lee, Gyeongsil, Son, Joung Sik, Kim, Kyae Hyung, Park, Sang Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918782/
https://www.ncbi.nlm.nih.gov/pubmed/33668451
http://dx.doi.org/10.3390/jcm10040745
_version_ 1783658003116851200
author Oh, Yun Hwan
Choi, Seulggie
Lee, Gyeongsil
Son, Joung Sik
Kim, Kyae Hyung
Park, Sang Min
author_facet Oh, Yun Hwan
Choi, Seulggie
Lee, Gyeongsil
Son, Joung Sik
Kim, Kyae Hyung
Park, Sang Min
author_sort Oh, Yun Hwan
collection PubMed
description In a cohort of 190,599 participants from The National Health Insurance Service-National Health Screening (NHIS-HEALS) study, we investigated the association of changes in the predicted body composition and metabolic profiles with the risk of metabolic syndrome (MetS) in the general population, which was hitherto incompletely elucidated. At baseline and follow-up examinations, the body composition, including lean body mass (LBM), body fat mass (BFM), and appendicular skeletal mass (ASM), were estimated using a prediction equation, and the risk of MetS was analyzed according to relative body composition changes. An increase in relative LBM and ASM decreased the risk of MetS in men and women (adjusted odds ratio (aOR), 0.78 and 0.80; 95% confidence interval (CI), 0.77–0.79 and 0.79–0.81, respectively; all p < 0.001). As relative LBM and ASM increased, the risk of MetS was more significantly reduced in the group with higher baseline BMI and body fat mass index (BFMI)(all p-trend < 0.001). In men, when the relative LBM increased (aOR, 0.68; 95% CI, 0.63–0.73), the risk of MetS was low despite increased BMI. Thus, our findings suggested that an increase in the relative LBM and ASM reduced the risk of MetS, whereas an increase in the relative BFMI increased the risk of MetS; this result was consistent in men despite an increase in BMI.
format Online
Article
Text
id pubmed-7918782
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79187822021-03-02 Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome Oh, Yun Hwan Choi, Seulggie Lee, Gyeongsil Son, Joung Sik Kim, Kyae Hyung Park, Sang Min J Clin Med Article In a cohort of 190,599 participants from The National Health Insurance Service-National Health Screening (NHIS-HEALS) study, we investigated the association of changes in the predicted body composition and metabolic profiles with the risk of metabolic syndrome (MetS) in the general population, which was hitherto incompletely elucidated. At baseline and follow-up examinations, the body composition, including lean body mass (LBM), body fat mass (BFM), and appendicular skeletal mass (ASM), were estimated using a prediction equation, and the risk of MetS was analyzed according to relative body composition changes. An increase in relative LBM and ASM decreased the risk of MetS in men and women (adjusted odds ratio (aOR), 0.78 and 0.80; 95% confidence interval (CI), 0.77–0.79 and 0.79–0.81, respectively; all p < 0.001). As relative LBM and ASM increased, the risk of MetS was more significantly reduced in the group with higher baseline BMI and body fat mass index (BFMI)(all p-trend < 0.001). In men, when the relative LBM increased (aOR, 0.68; 95% CI, 0.63–0.73), the risk of MetS was low despite increased BMI. Thus, our findings suggested that an increase in the relative LBM and ASM reduced the risk of MetS, whereas an increase in the relative BFMI increased the risk of MetS; this result was consistent in men despite an increase in BMI. MDPI 2021-02-13 /pmc/articles/PMC7918782/ /pubmed/33668451 http://dx.doi.org/10.3390/jcm10040745 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oh, Yun Hwan
Choi, Seulggie
Lee, Gyeongsil
Son, Joung Sik
Kim, Kyae Hyung
Park, Sang Min
Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
title Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
title_full Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
title_fullStr Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
title_full_unstemmed Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
title_short Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
title_sort changes in body composition are associated with metabolic changes and the risk of metabolic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918782/
https://www.ncbi.nlm.nih.gov/pubmed/33668451
http://dx.doi.org/10.3390/jcm10040745
work_keys_str_mv AT ohyunhwan changesinbodycompositionareassociatedwithmetabolicchangesandtheriskofmetabolicsyndrome
AT choiseulggie changesinbodycompositionareassociatedwithmetabolicchangesandtheriskofmetabolicsyndrome
AT leegyeongsil changesinbodycompositionareassociatedwithmetabolicchangesandtheriskofmetabolicsyndrome
AT sonjoungsik changesinbodycompositionareassociatedwithmetabolicchangesandtheriskofmetabolicsyndrome
AT kimkyaehyung changesinbodycompositionareassociatedwithmetabolicchangesandtheriskofmetabolicsyndrome
AT parksangmin changesinbodycompositionareassociatedwithmetabolicchangesandtheriskofmetabolicsyndrome