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Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
In a cohort of 190,599 participants from The National Health Insurance Service-National Health Screening (NHIS-HEALS) study, we investigated the association of changes in the predicted body composition and metabolic profiles with the risk of metabolic syndrome (MetS) in the general population, which...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918782/ https://www.ncbi.nlm.nih.gov/pubmed/33668451 http://dx.doi.org/10.3390/jcm10040745 |
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author | Oh, Yun Hwan Choi, Seulggie Lee, Gyeongsil Son, Joung Sik Kim, Kyae Hyung Park, Sang Min |
author_facet | Oh, Yun Hwan Choi, Seulggie Lee, Gyeongsil Son, Joung Sik Kim, Kyae Hyung Park, Sang Min |
author_sort | Oh, Yun Hwan |
collection | PubMed |
description | In a cohort of 190,599 participants from The National Health Insurance Service-National Health Screening (NHIS-HEALS) study, we investigated the association of changes in the predicted body composition and metabolic profiles with the risk of metabolic syndrome (MetS) in the general population, which was hitherto incompletely elucidated. At baseline and follow-up examinations, the body composition, including lean body mass (LBM), body fat mass (BFM), and appendicular skeletal mass (ASM), were estimated using a prediction equation, and the risk of MetS was analyzed according to relative body composition changes. An increase in relative LBM and ASM decreased the risk of MetS in men and women (adjusted odds ratio (aOR), 0.78 and 0.80; 95% confidence interval (CI), 0.77–0.79 and 0.79–0.81, respectively; all p < 0.001). As relative LBM and ASM increased, the risk of MetS was more significantly reduced in the group with higher baseline BMI and body fat mass index (BFMI)(all p-trend < 0.001). In men, when the relative LBM increased (aOR, 0.68; 95% CI, 0.63–0.73), the risk of MetS was low despite increased BMI. Thus, our findings suggested that an increase in the relative LBM and ASM reduced the risk of MetS, whereas an increase in the relative BFMI increased the risk of MetS; this result was consistent in men despite an increase in BMI. |
format | Online Article Text |
id | pubmed-7918782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79187822021-03-02 Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome Oh, Yun Hwan Choi, Seulggie Lee, Gyeongsil Son, Joung Sik Kim, Kyae Hyung Park, Sang Min J Clin Med Article In a cohort of 190,599 participants from The National Health Insurance Service-National Health Screening (NHIS-HEALS) study, we investigated the association of changes in the predicted body composition and metabolic profiles with the risk of metabolic syndrome (MetS) in the general population, which was hitherto incompletely elucidated. At baseline and follow-up examinations, the body composition, including lean body mass (LBM), body fat mass (BFM), and appendicular skeletal mass (ASM), were estimated using a prediction equation, and the risk of MetS was analyzed according to relative body composition changes. An increase in relative LBM and ASM decreased the risk of MetS in men and women (adjusted odds ratio (aOR), 0.78 and 0.80; 95% confidence interval (CI), 0.77–0.79 and 0.79–0.81, respectively; all p < 0.001). As relative LBM and ASM increased, the risk of MetS was more significantly reduced in the group with higher baseline BMI and body fat mass index (BFMI)(all p-trend < 0.001). In men, when the relative LBM increased (aOR, 0.68; 95% CI, 0.63–0.73), the risk of MetS was low despite increased BMI. Thus, our findings suggested that an increase in the relative LBM and ASM reduced the risk of MetS, whereas an increase in the relative BFMI increased the risk of MetS; this result was consistent in men despite an increase in BMI. MDPI 2021-02-13 /pmc/articles/PMC7918782/ /pubmed/33668451 http://dx.doi.org/10.3390/jcm10040745 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Oh, Yun Hwan Choi, Seulggie Lee, Gyeongsil Son, Joung Sik Kim, Kyae Hyung Park, Sang Min Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome |
title | Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome |
title_full | Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome |
title_fullStr | Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome |
title_full_unstemmed | Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome |
title_short | Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome |
title_sort | changes in body composition are associated with metabolic changes and the risk of metabolic syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918782/ https://www.ncbi.nlm.nih.gov/pubmed/33668451 http://dx.doi.org/10.3390/jcm10040745 |
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