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Vitamin D and Hospital Admission in Older Adults: A Prospective Association

The health effects of vitamin D are well documented, with increasing evidence of its roles beyond bone. There is, however, little evidence of the effects of vitamin D on hospitalisation among older adults. This study aimed to prospectively determine the relationship of vitamin D status in older adul...

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Autores principales: Beirne, Avril, McCarroll, Kevin, Walsh, James Bernard, Casey, Miriam, Laird, Eamon, McNulty, Helene, Ward, Mary, Hoey, Leane, Molloy, Anne M., Healy, Martin, Hughes, Catherine, Strain, Sean, Cunningham, Conal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918803/
https://www.ncbi.nlm.nih.gov/pubmed/33672800
http://dx.doi.org/10.3390/nu13020616
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author Beirne, Avril
McCarroll, Kevin
Walsh, James Bernard
Casey, Miriam
Laird, Eamon
McNulty, Helene
Ward, Mary
Hoey, Leane
Molloy, Anne M.
Healy, Martin
Hughes, Catherine
Strain, Sean
Cunningham, Conal
author_facet Beirne, Avril
McCarroll, Kevin
Walsh, James Bernard
Casey, Miriam
Laird, Eamon
McNulty, Helene
Ward, Mary
Hoey, Leane
Molloy, Anne M.
Healy, Martin
Hughes, Catherine
Strain, Sean
Cunningham, Conal
author_sort Beirne, Avril
collection PubMed
description The health effects of vitamin D are well documented, with increasing evidence of its roles beyond bone. There is, however, little evidence of the effects of vitamin D on hospitalisation among older adults. This study aimed to prospectively determine the relationship of vitamin D status in older adults with hospital admission and emergency department (ED) attendance. Trinity University of Ulster Department of Agriculture (TUDA) is a large cross-sectional study of older adults with a community population from three disease-defined cohorts (cognitive dysfunction, hypertension, and osteoporosis). Participants included in this analysis were recruited between 2008 and 2012. ED and hospital admission data were gathered from the date of TUDA participation until June 2013, with a mean follow up of 3.6 years. Of the 3093 participants, 1577 (50.9%) attended the ED during the period of follow-up. Attendees had lower mean serum 25(OH)D concentrations than non-attendees (59.1 vs. 70.6 nmol/L). Fully adjusted models showed an inverse association between vitamin D and ED attendance (Hazard Ratio (HR) 0.996; 95% Confidence Interval (CI) 0.995–0.998; p < 0.001). A total of 1269 participants (41%) were admitted to hospital during the follow-up. Those admitted had lower mean vitamin D concentrations (58.4 vs. 69.3 nmol/L, p < 0.001). In fully adjusted models, higher vitamin D was inversely associated with hospital admission (HR 0.996; 95% CI 0.994–0.998; p < 0.001) and length of stay (LOS) (β = −0.95, p = 0.006). This study showed independent prospective associations between vitamin D deficiency and increased hospitalisation by older adults. The need for further evaluation of current recommendations in relation to vitamin D supplementation, with consideration beyond bone health, is warranted and should focus on randomised controlled trials.
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spelling pubmed-79188032021-03-02 Vitamin D and Hospital Admission in Older Adults: A Prospective Association Beirne, Avril McCarroll, Kevin Walsh, James Bernard Casey, Miriam Laird, Eamon McNulty, Helene Ward, Mary Hoey, Leane Molloy, Anne M. Healy, Martin Hughes, Catherine Strain, Sean Cunningham, Conal Nutrients Article The health effects of vitamin D are well documented, with increasing evidence of its roles beyond bone. There is, however, little evidence of the effects of vitamin D on hospitalisation among older adults. This study aimed to prospectively determine the relationship of vitamin D status in older adults with hospital admission and emergency department (ED) attendance. Trinity University of Ulster Department of Agriculture (TUDA) is a large cross-sectional study of older adults with a community population from three disease-defined cohorts (cognitive dysfunction, hypertension, and osteoporosis). Participants included in this analysis were recruited between 2008 and 2012. ED and hospital admission data were gathered from the date of TUDA participation until June 2013, with a mean follow up of 3.6 years. Of the 3093 participants, 1577 (50.9%) attended the ED during the period of follow-up. Attendees had lower mean serum 25(OH)D concentrations than non-attendees (59.1 vs. 70.6 nmol/L). Fully adjusted models showed an inverse association between vitamin D and ED attendance (Hazard Ratio (HR) 0.996; 95% Confidence Interval (CI) 0.995–0.998; p < 0.001). A total of 1269 participants (41%) were admitted to hospital during the follow-up. Those admitted had lower mean vitamin D concentrations (58.4 vs. 69.3 nmol/L, p < 0.001). In fully adjusted models, higher vitamin D was inversely associated with hospital admission (HR 0.996; 95% CI 0.994–0.998; p < 0.001) and length of stay (LOS) (β = −0.95, p = 0.006). This study showed independent prospective associations between vitamin D deficiency and increased hospitalisation by older adults. The need for further evaluation of current recommendations in relation to vitamin D supplementation, with consideration beyond bone health, is warranted and should focus on randomised controlled trials. MDPI 2021-02-14 /pmc/articles/PMC7918803/ /pubmed/33672800 http://dx.doi.org/10.3390/nu13020616 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beirne, Avril
McCarroll, Kevin
Walsh, James Bernard
Casey, Miriam
Laird, Eamon
McNulty, Helene
Ward, Mary
Hoey, Leane
Molloy, Anne M.
Healy, Martin
Hughes, Catherine
Strain, Sean
Cunningham, Conal
Vitamin D and Hospital Admission in Older Adults: A Prospective Association
title Vitamin D and Hospital Admission in Older Adults: A Prospective Association
title_full Vitamin D and Hospital Admission in Older Adults: A Prospective Association
title_fullStr Vitamin D and Hospital Admission in Older Adults: A Prospective Association
title_full_unstemmed Vitamin D and Hospital Admission in Older Adults: A Prospective Association
title_short Vitamin D and Hospital Admission in Older Adults: A Prospective Association
title_sort vitamin d and hospital admission in older adults: a prospective association
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918803/
https://www.ncbi.nlm.nih.gov/pubmed/33672800
http://dx.doi.org/10.3390/nu13020616
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