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The Effect of Octapeptide Repeats on Prion Folding and Misfolding

Misfolding of prion protein (PrP) into amyloid aggregates is the central feature of prion diseases. PrP has an amyloidogenic C-terminal domain with three α-helices and a flexible tail in the N-terminal domain in which multiple octapeptide repeats are present in most mammals. The role of the octapept...

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Detalles Bibliográficos
Autores principales:	Yu, Kun-Hua, Huang, Mei-Yu, Lee, Yi-Ru, Lin, Yu-Kie, Chen, Hau-Ren, Lee, Cheng-I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918816/ https://www.ncbi.nlm.nih.gov/pubmed/33670336 http://dx.doi.org/10.3390/ijms22041800

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