Cargando…

Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults

Adaptive as well as innate immune traits are variously affected by environmental and genetic influences, but little is known about the impact of genetics on the diversity, differentiation and functionality of γδ T cells in humans. Here, we analyzed a cohort of 95 middle-aged twins from the Danish Tw...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beucke, Nicola, Wingerter, Svenja, Hähnel, Karin, Larsen, Lisbeth Aagaard, Christensen, Kaare, Pawelec, Graham, Wistuba-Hamprecht, Kilian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918850/ https://www.ncbi.nlm.nih.gov/pubmed/33670279 http://dx.doi.org/10.3390/cells10020373

Ejemplares similares

Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II
por: Wistuba-Hamprecht, Kilian, et al.
Publicado: (2015)

Impact of Cytomegalovirus Infection and Genetic Background on the Frequencies of Peripheral Blood Suppressor Cells in Human Twins
por: Goldeck, David, et al.
Publicado: (2021)

Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus
por: Wistuba-Hamprecht, Kilian, et al.
Publicado: (2013)

Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells
por: Ziegler, Hendrik, et al.
Publicado: (2014)

Immune Signatures and Survival of Patients With Metastatic Melanoma, Renal Cancer, and Breast Cancer
por: Wistuba-Hamprecht, Kilian, et al.
Publicado: (2020)

Suppressive activity of Vδ2(+) γδ T cells on αβ T cells is licensed by TCR signaling and correlates with signal strength
por: Schilbach, Karin, et al.
Publicado: (2020)

Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes
por: Wang, Baoping, et al.
Publicado: (1998)

Human αβ and γδ T Cells in Skin Immunity and Disease
por: Cruz, Michelle S., et al.
Publicado: (2018)

Vδ2+ and α/Δ T cells show divergent trajectories during human aging
por: Tan, Crystal Tze Ying, et al.
Publicado: (2016)

Immunomonitoring of Human Breast Milk Cells During HCMV-Reactivation
por: Lazar, Katrin, et al.
Publicado: (2021)

Lymph act, TCR αβ, TCR γδ cells in peripheral blood in children with juvenile idiopathic arthritis
por: Mazur-Zielinska, H
Publicado: (2008)

Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression
por: Muñoz-Ruiz, Miguel, et al.
Publicado: (2013)

The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development
por: Seeland, Isabel, et al.
Publicado: (2018)

Lymph node γδ and αβ CD8(+) T cells share migratory properties
por: Ugur, Milas, et al.
Publicado: (2018)

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification
por: Wiede, Florian, et al.
Publicado: (2017)

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans
por: Edwards, Sarah C., et al.
Publicado: (2020)

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells
por: Terrence, Kathleen, et al.
Publicado: (2000)

γδ T cells shape memory-phenotype αβ T cell populations in non-immunized mice
por: Phalke, Swati Popat, et al.
Publicado: (2019)

Association between αβ and γδ T-cell subsets and clinicopathological characteristics in patients with breast cancer
por: Zhang, Meng, et al.
Publicado: (2020)

αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals
por: Aghaallaei, Narges, et al.
Publicado: (2021)

The molecular bases of δ/αβ T cell–mediated antigen recognition
por: Pellicci, Daniel G., et al.
Publicado: (2014)

T cell receptor–instructed αβ versus γδ lineage commitment revealed by single-cell analysis
por: Kreslavsky, Taras, et al.
Publicado: (2008)

Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate
por: Garbe, Annette I., et al.
Publicado: (2006)

Evidence That γδ versus αβ T Cell Fate Determination Is Initiated Independently of T Cell Receptor Signaling
por: Kang, Joonsoo, et al.
Publicado: (2001)

T-Cell Subpopulations αβ and γδ in Cord Blood of Very Preterm Infants: the Influence of Intrauterine Infection
por: Serwatowska-Bargieł, Agata, et al.
Publicado: (2013)

αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence
por: Ishihara, Mikiya, et al.
Publicado: (2023)

Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ(−/−), PPARδ(−/−), PPARγδ(−/−), or LXRαβ(−/−) bone marrow
por: Marathe, Chaitra, et al.
Publicado: (2009)

Radiation-induced DNA damage and repair in human γδ and αβ T-lymphocytes analysed by the alkaline comet assay
por: Lisowska, Halina, et al.
Publicado: (2010)

γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice
por: Zhang, Xiaoli, et al.
Publicado: (2017)

Immunological Characteristics between αβ T (DC) and γδ T (DC) Cells in the Spleen of Breast Cancer-Induced Mice
por: Silva, Polyana Barbosa, et al.
Publicado: (2021)

Peripheral PD-1+CD56+ T-cell frequencies correlate with outcome in stage IV melanoma under PD-1 blockade
por: Bochem, Jonas, et al.
Publicado: (2019)

CD4-CD8-αβ and γδ T Cells Display Inflammatory and Regulatory Potentials during Human Tuberculosis
por: Pinheiro, Melina B., et al.
Publicado: (2012)

Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells
por: Fleischer, Lauren C., et al.
Publicado: (2020)

The γδ variant of T cell large granular lymphocyte leukemia is very similar to the common αβ type: report of two cases
por: Shaw, Gene R., et al.
Publicado: (2008)

Chicken CRTAM Binds Nectin-Like 2 Ligand and Is Upregulated on CD8(+) αβ and γδ T Lymphocytes with Different Kinetics
por: Zechmann, Maria, et al.
Publicado: (2013)

Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis
por: Guo, Xi-zhi J, et al.
Publicado: (2016)

αβ-T Cells Engineered to Express γδ-T Cell Receptors Can Kill Neuroblastoma Organoids Independent of MHC-I Expression
por: Strijker, Josephine G. M., et al.
Publicado: (2021)

The Eδ enhancer controls the generation of CD4(−)CD8(−) αβTCR-expressing T cells that can give rise to different lineages of αβ T cells
por: Aifantis, Iannis, et al.
Publicado: (2006)

The Distinct Contributions of Murine T Cell Receptor (TCR)γδ(+) and TCRαβ(+) T Cells to Different Stages of Chemically Induced Skin Cancer
por: Girardi, Michael, et al.
Publicado: (2003)

Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
por: Van de Walle, Inge, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_o4ch1ajsmfpknc0tjq8rb5qfvq