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Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy

Among the different effects of bariatric surgery, here we focus on bone-derived inflammatory molecules, and in particular, sclerostin; an osteocyte product potentially associated with cardio-metabolic diseases. In 94 morbidly obese patients undergoing laparoscopic sleeve gastrectomy (SG), over-time...

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Autores principales: Carbone, Federico, Nulli Migliola, Elisa, Bonaventura, Aldo, Vecchié, Alessandra, De Vuono, Stefano, Ricci, Maria Anastasia, Vaudo, Gaetano, Boni, Marcello, Ministrini, Stefano, Lupattelli, Graziana, Montecucco, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918938/
https://www.ncbi.nlm.nih.gov/pubmed/33671861
http://dx.doi.org/10.3390/nu13020623
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author Carbone, Federico
Nulli Migliola, Elisa
Bonaventura, Aldo
Vecchié, Alessandra
De Vuono, Stefano
Ricci, Maria Anastasia
Vaudo, Gaetano
Boni, Marcello
Ministrini, Stefano
Lupattelli, Graziana
Montecucco, Fabrizio
author_facet Carbone, Federico
Nulli Migliola, Elisa
Bonaventura, Aldo
Vecchié, Alessandra
De Vuono, Stefano
Ricci, Maria Anastasia
Vaudo, Gaetano
Boni, Marcello
Ministrini, Stefano
Lupattelli, Graziana
Montecucco, Fabrizio
author_sort Carbone, Federico
collection PubMed
description Among the different effects of bariatric surgery, here we focus on bone-derived inflammatory molecules, and in particular, sclerostin; an osteocyte product potentially associated with cardio-metabolic diseases. In 94 morbidly obese patients undergoing laparoscopic sleeve gastrectomy (SG), over-time changes in anthropometric and biochemical measures—including insulin resistance (IR) indexes—were correlated with serum sclerostin levels. Sclerostin was positively associated with anthropometric indexes of obesity, and inversely with IR, namely homeostatic model assessment for peripheral insulin sensitivity (HOMA2%S) (r = −0.218; p = 0.045). Sclerostin emerged as the only significant predictor of HOMA2-%S normalization, independently of demographic and anthropometric variables (OR 1.01 (95% CI 1.00–1.02); p = 0.024). We also identified two distinct patterns of serum sclerostin change: the higher/lower sclerostin levels at baseline, the greater their post-surgical reduction/increase (p < 0.001 for all subgroups). Among those two patterns, especially the post-surgery increase in serum sclerostin was associated with lean mass reduction, without any association with IR indexes. Although counterintuitive, this change was likely dependent on the post-surgical increase in bone turnover. In conclusion, baseline serum levels of sclerostin correlate with anthropometric measures of obesity and IR, and the ability to predict glycemic improvements after SG. Specifically, serum sclerostin was closely associated with peripheral insulin sensitivity (HOMA2-%S), thus supporting the role of skeletal muscle/bone interactions in metabolic diseases.
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spelling pubmed-79189382021-03-02 Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy Carbone, Federico Nulli Migliola, Elisa Bonaventura, Aldo Vecchié, Alessandra De Vuono, Stefano Ricci, Maria Anastasia Vaudo, Gaetano Boni, Marcello Ministrini, Stefano Lupattelli, Graziana Montecucco, Fabrizio Nutrients Article Among the different effects of bariatric surgery, here we focus on bone-derived inflammatory molecules, and in particular, sclerostin; an osteocyte product potentially associated with cardio-metabolic diseases. In 94 morbidly obese patients undergoing laparoscopic sleeve gastrectomy (SG), over-time changes in anthropometric and biochemical measures—including insulin resistance (IR) indexes—were correlated with serum sclerostin levels. Sclerostin was positively associated with anthropometric indexes of obesity, and inversely with IR, namely homeostatic model assessment for peripheral insulin sensitivity (HOMA2%S) (r = −0.218; p = 0.045). Sclerostin emerged as the only significant predictor of HOMA2-%S normalization, independently of demographic and anthropometric variables (OR 1.01 (95% CI 1.00–1.02); p = 0.024). We also identified two distinct patterns of serum sclerostin change: the higher/lower sclerostin levels at baseline, the greater their post-surgical reduction/increase (p < 0.001 for all subgroups). Among those two patterns, especially the post-surgery increase in serum sclerostin was associated with lean mass reduction, without any association with IR indexes. Although counterintuitive, this change was likely dependent on the post-surgical increase in bone turnover. In conclusion, baseline serum levels of sclerostin correlate with anthropometric measures of obesity and IR, and the ability to predict glycemic improvements after SG. Specifically, serum sclerostin was closely associated with peripheral insulin sensitivity (HOMA2-%S), thus supporting the role of skeletal muscle/bone interactions in metabolic diseases. MDPI 2021-02-15 /pmc/articles/PMC7918938/ /pubmed/33671861 http://dx.doi.org/10.3390/nu13020623 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carbone, Federico
Nulli Migliola, Elisa
Bonaventura, Aldo
Vecchié, Alessandra
De Vuono, Stefano
Ricci, Maria Anastasia
Vaudo, Gaetano
Boni, Marcello
Ministrini, Stefano
Lupattelli, Graziana
Montecucco, Fabrizio
Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
title Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
title_full Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
title_fullStr Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
title_full_unstemmed Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
title_short Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
title_sort circulating levels of sclerostin predict glycemic improvement after sleeve gastrectomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918938/
https://www.ncbi.nlm.nih.gov/pubmed/33671861
http://dx.doi.org/10.3390/nu13020623
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