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HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort

The aim of this study was to evaluate whether the presence of anti-hepatitis B (HBV) c antibodies (HBcAb positivity) could influence the control of Human Immunodeficiency Virus (HIV) viremia in patients living with HIV (PLWH) who switch a to two-drug antiretroviral therapy (2DR) containing lamivudin...

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Autores principales: Malagnino, Vincenzo, Teti, Elisabetta, Compagno, Mirko, Coppola, Luigi, Salpini, Romina, Svicher, Valentina, Basso, Monica, Battagin, Giuliana, Panese, Sandro, Rossi, Maria Cristina, Scaggiante, Renzo, Zago, Daniela, Iannetta, Marco, Parisi, Saverio Giuseppe, Andreoni, Massimo, Sarmati, Loredana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919011/
https://www.ncbi.nlm.nih.gov/pubmed/33671934
http://dx.doi.org/10.3390/microorganisms9020396
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author Malagnino, Vincenzo
Teti, Elisabetta
Compagno, Mirko
Coppola, Luigi
Salpini, Romina
Svicher, Valentina
Basso, Monica
Battagin, Giuliana
Panese, Sandro
Rossi, Maria Cristina
Scaggiante, Renzo
Zago, Daniela
Iannetta, Marco
Parisi, Saverio Giuseppe
Andreoni, Massimo
Sarmati, Loredana
author_facet Malagnino, Vincenzo
Teti, Elisabetta
Compagno, Mirko
Coppola, Luigi
Salpini, Romina
Svicher, Valentina
Basso, Monica
Battagin, Giuliana
Panese, Sandro
Rossi, Maria Cristina
Scaggiante, Renzo
Zago, Daniela
Iannetta, Marco
Parisi, Saverio Giuseppe
Andreoni, Massimo
Sarmati, Loredana
author_sort Malagnino, Vincenzo
collection PubMed
description The aim of this study was to evaluate whether the presence of anti-hepatitis B (HBV) c antibodies (HBcAb positivity) could influence the control of Human Immunodeficiency Virus (HIV) viremia in patients living with HIV (PLWH) who switch a to two-drug antiretroviral therapy (2DR) containing lamivudine (3TC) (2DR-3TC). A retrospective observational multicenter study was conducted on 166 PLWH switching to the 2DR-3TC-based regimen: 58 HBcAb-positive and 108 HBcAb-negative patients. The HBcAb-positive PLWH group demonstrated a significantly higher percentage of subjects with very low-level viremia at all time points after switching (6th month: <31% vs. 17.6%, p = 0.047; 12th month 34% vs. 27.5%, p = 0.001; 24th month 37% vs. 34.2, p = 0.003 of the HBcAb-positive and HBcAb-negative groups, respectively) and a higher percentage of subjects with detectable HIV RNA greater than 20 copies/mL 12 and 24 months after switching (12 months 32% vs. 11%, p = 0.001; 24 months 37% vs. 13.9%, p = 0.003 of the HBcAb-positive and HBcAb-negative groups, respectively). Logistic regression analysis showed that an increase in age of ten years (OR 2.48 (95% CI 1.58–3.89), p < 0.0001) and the presence of HBcAb positivity (OR 2.7 (5% CI 1.05–6.9), p = 0.038) increased the risk of detectability of HIV RNA by nearly three-fold after switching to 2DR-3TC.
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spelling pubmed-79190112021-03-02 HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort Malagnino, Vincenzo Teti, Elisabetta Compagno, Mirko Coppola, Luigi Salpini, Romina Svicher, Valentina Basso, Monica Battagin, Giuliana Panese, Sandro Rossi, Maria Cristina Scaggiante, Renzo Zago, Daniela Iannetta, Marco Parisi, Saverio Giuseppe Andreoni, Massimo Sarmati, Loredana Microorganisms Article The aim of this study was to evaluate whether the presence of anti-hepatitis B (HBV) c antibodies (HBcAb positivity) could influence the control of Human Immunodeficiency Virus (HIV) viremia in patients living with HIV (PLWH) who switch a to two-drug antiretroviral therapy (2DR) containing lamivudine (3TC) (2DR-3TC). A retrospective observational multicenter study was conducted on 166 PLWH switching to the 2DR-3TC-based regimen: 58 HBcAb-positive and 108 HBcAb-negative patients. The HBcAb-positive PLWH group demonstrated a significantly higher percentage of subjects with very low-level viremia at all time points after switching (6th month: <31% vs. 17.6%, p = 0.047; 12th month 34% vs. 27.5%, p = 0.001; 24th month 37% vs. 34.2, p = 0.003 of the HBcAb-positive and HBcAb-negative groups, respectively) and a higher percentage of subjects with detectable HIV RNA greater than 20 copies/mL 12 and 24 months after switching (12 months 32% vs. 11%, p = 0.001; 24 months 37% vs. 13.9%, p = 0.003 of the HBcAb-positive and HBcAb-negative groups, respectively). Logistic regression analysis showed that an increase in age of ten years (OR 2.48 (95% CI 1.58–3.89), p < 0.0001) and the presence of HBcAb positivity (OR 2.7 (5% CI 1.05–6.9), p = 0.038) increased the risk of detectability of HIV RNA by nearly three-fold after switching to 2DR-3TC. MDPI 2021-02-15 /pmc/articles/PMC7919011/ /pubmed/33671934 http://dx.doi.org/10.3390/microorganisms9020396 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Malagnino, Vincenzo
Teti, Elisabetta
Compagno, Mirko
Coppola, Luigi
Salpini, Romina
Svicher, Valentina
Basso, Monica
Battagin, Giuliana
Panese, Sandro
Rossi, Maria Cristina
Scaggiante, Renzo
Zago, Daniela
Iannetta, Marco
Parisi, Saverio Giuseppe
Andreoni, Massimo
Sarmati, Loredana
HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort
title HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort
title_full HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort
title_fullStr HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort
title_full_unstemmed HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort
title_short HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort
title_sort hbcab positivity is a risk factor for an increased detectability of hiv rna after switching to a two-drug regimen lamivudine-based (2dr-3tc-based) treatment: analysis of a multicenter italian cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919011/
https://www.ncbi.nlm.nih.gov/pubmed/33671934
http://dx.doi.org/10.3390/microorganisms9020396
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