Cargando…
Clinical Efficacy and Safety of Low-Level Laser Therapy in Patients with Perennial Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial
Allergic rhinitis (AR) is a common disease that interferes with the daily activities and reduces the quality of life. Conventional treatments often do not provide complete resolution of the symptoms, and many new treatment modalities have been tried. This study aimed to evaluate the efficacy and saf...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919054/ https://www.ncbi.nlm.nih.gov/pubmed/33671931 http://dx.doi.org/10.3390/jcm10040772 |
_version_ | 1783658062738882560 |
---|---|
author | Jung, Hahn Jin Chung, Young-Jun Choi, Young-Seok Chung, Phil Sang Mo, Ji-Hun |
author_facet | Jung, Hahn Jin Chung, Young-Jun Choi, Young-Seok Chung, Phil Sang Mo, Ji-Hun |
author_sort | Jung, Hahn Jin |
collection | PubMed |
description | Allergic rhinitis (AR) is a common disease that interferes with the daily activities and reduces the quality of life. Conventional treatments often do not provide complete resolution of the symptoms, and many new treatment modalities have been tried. This study aimed to evaluate the efficacy and safety of low-level laser therapy (LLLT) for AR in a randomized, double-blind, placebo-controlled trial. Patients diagnosed with AR were randomly allocated to receive LLLT or sham treatment. The primary outcome was a change in the reflective total nasal symptom score (TNSS). The secondary outcome was quality of life scores assessed using the Rhinoconjunctivitis Quality of Life Questionnaire. Incidences of adverse events were also recorded. Among 67 randomized subjects, 41 subjects (22 in LLLT group and 19 in sham treatment group) were included for efficacy analysis. The LLLT group showed a significantly improved TNSS score compared to the sham treatment group for decreasing AR symptom severity (p = 0.011) and improving quality of life regarding nasal symptoms (p = 0.036) at the end of treatment. Throughout the treatment period, no severe adverse events occurred. This clinical trial showed that LLLT is an effective and safe option for the management of AR regarding symptom relief and quality of life improvement. |
format | Online Article Text |
id | pubmed-7919054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79190542021-03-02 Clinical Efficacy and Safety of Low-Level Laser Therapy in Patients with Perennial Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial Jung, Hahn Jin Chung, Young-Jun Choi, Young-Seok Chung, Phil Sang Mo, Ji-Hun J Clin Med Article Allergic rhinitis (AR) is a common disease that interferes with the daily activities and reduces the quality of life. Conventional treatments often do not provide complete resolution of the symptoms, and many new treatment modalities have been tried. This study aimed to evaluate the efficacy and safety of low-level laser therapy (LLLT) for AR in a randomized, double-blind, placebo-controlled trial. Patients diagnosed with AR were randomly allocated to receive LLLT or sham treatment. The primary outcome was a change in the reflective total nasal symptom score (TNSS). The secondary outcome was quality of life scores assessed using the Rhinoconjunctivitis Quality of Life Questionnaire. Incidences of adverse events were also recorded. Among 67 randomized subjects, 41 subjects (22 in LLLT group and 19 in sham treatment group) were included for efficacy analysis. The LLLT group showed a significantly improved TNSS score compared to the sham treatment group for decreasing AR symptom severity (p = 0.011) and improving quality of life regarding nasal symptoms (p = 0.036) at the end of treatment. Throughout the treatment period, no severe adverse events occurred. This clinical trial showed that LLLT is an effective and safe option for the management of AR regarding symptom relief and quality of life improvement. MDPI 2021-02-15 /pmc/articles/PMC7919054/ /pubmed/33671931 http://dx.doi.org/10.3390/jcm10040772 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jung, Hahn Jin Chung, Young-Jun Choi, Young-Seok Chung, Phil Sang Mo, Ji-Hun Clinical Efficacy and Safety of Low-Level Laser Therapy in Patients with Perennial Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial |
title | Clinical Efficacy and Safety of Low-Level Laser Therapy in Patients with Perennial Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_full | Clinical Efficacy and Safety of Low-Level Laser Therapy in Patients with Perennial Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_fullStr | Clinical Efficacy and Safety of Low-Level Laser Therapy in Patients with Perennial Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_full_unstemmed | Clinical Efficacy and Safety of Low-Level Laser Therapy in Patients with Perennial Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_short | Clinical Efficacy and Safety of Low-Level Laser Therapy in Patients with Perennial Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial |
title_sort | clinical efficacy and safety of low-level laser therapy in patients with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919054/ https://www.ncbi.nlm.nih.gov/pubmed/33671931 http://dx.doi.org/10.3390/jcm10040772 |
work_keys_str_mv | AT junghahnjin clinicalefficacyandsafetyoflowlevellasertherapyinpatientswithperennialallergicrhinitisarandomizeddoubleblindplacebocontrolledtrial AT chungyoungjun clinicalefficacyandsafetyoflowlevellasertherapyinpatientswithperennialallergicrhinitisarandomizeddoubleblindplacebocontrolledtrial AT choiyoungseok clinicalefficacyandsafetyoflowlevellasertherapyinpatientswithperennialallergicrhinitisarandomizeddoubleblindplacebocontrolledtrial AT chungphilsang clinicalefficacyandsafetyoflowlevellasertherapyinpatientswithperennialallergicrhinitisarandomizeddoubleblindplacebocontrolledtrial AT mojihun clinicalefficacyandsafetyoflowlevellasertherapyinpatientswithperennialallergicrhinitisarandomizeddoubleblindplacebocontrolledtrial |