The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)

BACKGROUND: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Hai-Yang, Xu, Yan, Qiao, Chun-You, Peng, Yi, Ding, Qi, Wang, Li-Zhong, Yan, Jun-Fei, Hou, Yuan, Di, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919063/
https://www.ncbi.nlm.nih.gov/pubmed/33641668
http://dx.doi.org/10.1186/s41016-021-00234-4
_version_ 1783658063875538944
author Ma, Hai-Yang
Xu, Yan
Qiao, Chun-You
Peng, Yi
Ding, Qi
Wang, Li-Zhong
Yan, Jun-Fei
Hou, Yuan
Di, Fei
author_facet Ma, Hai-Yang
Xu, Yan
Qiao, Chun-You
Peng, Yi
Ding, Qi
Wang, Li-Zhong
Yan, Jun-Fei
Hou, Yuan
Di, Fei
author_sort Ma, Hai-Yang
collection PubMed
description BACKGROUND: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. METHODS: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. RESULTS: Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. CONCLUSIONS: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.
format Online
Article
Text
id pubmed-7919063
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-79190632021-03-02 The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1) Ma, Hai-Yang Xu, Yan Qiao, Chun-You Peng, Yi Ding, Qi Wang, Li-Zhong Yan, Jun-Fei Hou, Yuan Di, Fei Chin Neurosurg J Research BACKGROUND: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. METHODS: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively. RESULTS: Furthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues. CONCLUSIONS: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH. BioMed Central 2021-03-01 /pmc/articles/PMC7919063/ /pubmed/33641668 http://dx.doi.org/10.1186/s41016-021-00234-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ma, Hai-Yang
Xu, Yan
Qiao, Chun-You
Peng, Yi
Ding, Qi
Wang, Li-Zhong
Yan, Jun-Fei
Hou, Yuan
Di, Fei
The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)
title The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)
title_full The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)
title_fullStr The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)
title_full_unstemmed The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)
title_short The progression of intracerebral hemorrhage (ICH) is related to the expression of integrin Β1 (ITGB1)
title_sort progression of intracerebral hemorrhage (ich) is related to the expression of integrin β1 (itgb1)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919063/
https://www.ncbi.nlm.nih.gov/pubmed/33641668
http://dx.doi.org/10.1186/s41016-021-00234-4
work_keys_str_mv AT mahaiyang theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT xuyan theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT qiaochunyou theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT pengyi theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT dingqi theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT wanglizhong theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT yanjunfei theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT houyuan theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT difei theprogressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT mahaiyang progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT xuyan progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT qiaochunyou progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT pengyi progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT dingqi progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT wanglizhong progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT yanjunfei progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT houyuan progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1
AT difei progressionofintracerebralhemorrhageichisrelatedtotheexpressionofintegrinb1itgb1

Ejemplares similares