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Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial

BACKGROUND: To investigate the optimal dose of dexmedetomidine to maintain hemodynamic stability, prevent of cough and minimize postoperative pain for patients undergoing laparoscopic cholecystectomy. METHODS: One hundred twenty patients were randomly divided into D(1), D(2), D(3) and NS groups, and...

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Autores principales: Ye, Qin, Wang, Fangjun, Xu, Hongchun, Wu, Le, Gao, Xiaopei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919082/
https://www.ncbi.nlm.nih.gov/pubmed/33648441
http://dx.doi.org/10.1186/s12871-021-01283-z
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author Ye, Qin
Wang, Fangjun
Xu, Hongchun
Wu, Le
Gao, Xiaopei
author_facet Ye, Qin
Wang, Fangjun
Xu, Hongchun
Wu, Le
Gao, Xiaopei
author_sort Ye, Qin
collection PubMed
description BACKGROUND: To investigate the optimal dose of dexmedetomidine to maintain hemodynamic stability, prevent of cough and minimize postoperative pain for patients undergoing laparoscopic cholecystectomy. METHODS: One hundred twenty patients were randomly divided into D(1), D(2), D(3) and NS groups, and dexmedetomidine 0.4, 0.6, 0.8μg/kg and normal saline were administrated respectively. Patients’ heart rate, systolic blood pressure and diastolic blood pressure were measured at T(1)-T(7). The incidence of cough was recorded. Other parameters were noted, the time of spontaneous respiratory recovery and extubation, visual analogue scale scores and dosage of tramadol. RESULTS: The heart rate, systolic blood pressure and diastolic blood pressure of D(2) and D(3) groups has smaller fluctuations at T2–3 and T7 compared with NS and D(1) groups (P < 0.05). The incidence of cough was lower in D(2) and D(3) groups than NS group (P < 0.05). The visual analogue scale scores and tramadol dosage of D(2) and D(3) groups were lower than NS group (P < 0.05). The time of spontaneous respiratory recovery and extubation in D(3) group was longer than that in D(1) and D(2) groups (P < 0.05). CONCLUSIONS: Intravenous infusion of 0.6μg/kg dexmedetomidine before induction can maintain hemodynamic stability, decrease cough during emergence, relieve postoperative pain of patients undergoing laparoscopic cholecystectomy. TRIAL REGISTRATION: ChiCTR1900024801, registered at the Chinese Clinical Trial Registry, principal investigator: Qin Ye, date of registration: July 28, 2019.
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spelling pubmed-79190822021-03-02 Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial Ye, Qin Wang, Fangjun Xu, Hongchun Wu, Le Gao, Xiaopei BMC Anesthesiol Research Article BACKGROUND: To investigate the optimal dose of dexmedetomidine to maintain hemodynamic stability, prevent of cough and minimize postoperative pain for patients undergoing laparoscopic cholecystectomy. METHODS: One hundred twenty patients were randomly divided into D(1), D(2), D(3) and NS groups, and dexmedetomidine 0.4, 0.6, 0.8μg/kg and normal saline were administrated respectively. Patients’ heart rate, systolic blood pressure and diastolic blood pressure were measured at T(1)-T(7). The incidence of cough was recorded. Other parameters were noted, the time of spontaneous respiratory recovery and extubation, visual analogue scale scores and dosage of tramadol. RESULTS: The heart rate, systolic blood pressure and diastolic blood pressure of D(2) and D(3) groups has smaller fluctuations at T2–3 and T7 compared with NS and D(1) groups (P < 0.05). The incidence of cough was lower in D(2) and D(3) groups than NS group (P < 0.05). The visual analogue scale scores and tramadol dosage of D(2) and D(3) groups were lower than NS group (P < 0.05). The time of spontaneous respiratory recovery and extubation in D(3) group was longer than that in D(1) and D(2) groups (P < 0.05). CONCLUSIONS: Intravenous infusion of 0.6μg/kg dexmedetomidine before induction can maintain hemodynamic stability, decrease cough during emergence, relieve postoperative pain of patients undergoing laparoscopic cholecystectomy. TRIAL REGISTRATION: ChiCTR1900024801, registered at the Chinese Clinical Trial Registry, principal investigator: Qin Ye, date of registration: July 28, 2019. BioMed Central 2021-03-01 /pmc/articles/PMC7919082/ /pubmed/33648441 http://dx.doi.org/10.1186/s12871-021-01283-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Ye, Qin
Wang, Fangjun
Xu, Hongchun
Wu, Le
Gao, Xiaopei
Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
title Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
title_full Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
title_fullStr Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
title_full_unstemmed Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
title_short Effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
title_sort effects of dexmedetomidine on intraoperative hemodynamics, recovery profile and postoperative pain in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919082/
https://www.ncbi.nlm.nih.gov/pubmed/33648441
http://dx.doi.org/10.1186/s12871-021-01283-z
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