Immune checkpoint inhibitors‐induced eosinophilic pneumonia: A case report

A 78‐year‐old male with renal cell carcinoma was treated with combined immunotherapy of nivolumab and ipilimumab. After four courses of the treatment, a chest computed tomography (CT) revealed newly formed ground‐glass opacities (GGOs) in both the lower lung lobes; drug‐induced pneumonia was specula...

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Autores principales: Hara, Kanako, Yamasaki, Kei, Tahara, Masahiro, Kimuro, Rieko, Yamaguchi, Yudai, Suzuki, Yu, Kawabata, Hiroki, Kawanami, Toshinori, Fujimoto, Naohiro, Yatera, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919115/
https://www.ncbi.nlm.nih.gov/pubmed/33476070
http://dx.doi.org/10.1111/1759-7714.13848
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author Hara, Kanako
Yamasaki, Kei
Tahara, Masahiro
Kimuro, Rieko
Yamaguchi, Yudai
Suzuki, Yu
Kawabata, Hiroki
Kawanami, Toshinori
Fujimoto, Naohiro
Yatera, Kazuhiro
author_facet Hara, Kanako
Yamasaki, Kei
Tahara, Masahiro
Kimuro, Rieko
Yamaguchi, Yudai
Suzuki, Yu
Kawabata, Hiroki
Kawanami, Toshinori
Fujimoto, Naohiro
Yatera, Kazuhiro
author_sort Hara, Kanako
collection PubMed
description A 78‐year‐old male with renal cell carcinoma was treated with combined immunotherapy of nivolumab and ipilimumab. After four courses of the treatment, a chest computed tomography (CT) revealed newly formed ground‐glass opacities (GGOs) in both the lower lung lobes; drug‐induced pneumonia was speculated. Eosinophil counts were elevated in both peripheral blood and bronchoalveolar lavage fluid. Both the immune checkpoint inhibitors (ICIs) were discontinued, following which the chest CT findings improved. Based on these findings, a diagnosis of ICI‐induced eosinophilic pneumonia was made. Hence, clinicians should be wary of the risk of eosinophilic pneumonia during ICI‐anticancer therapy.
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spelling pubmed-79191152021-03-05 Immune checkpoint inhibitors‐induced eosinophilic pneumonia: A case report Hara, Kanako Yamasaki, Kei Tahara, Masahiro Kimuro, Rieko Yamaguchi, Yudai Suzuki, Yu Kawabata, Hiroki Kawanami, Toshinori Fujimoto, Naohiro Yatera, Kazuhiro Thorac Cancer Case Reports A 78‐year‐old male with renal cell carcinoma was treated with combined immunotherapy of nivolumab and ipilimumab. After four courses of the treatment, a chest computed tomography (CT) revealed newly formed ground‐glass opacities (GGOs) in both the lower lung lobes; drug‐induced pneumonia was speculated. Eosinophil counts were elevated in both peripheral blood and bronchoalveolar lavage fluid. Both the immune checkpoint inhibitors (ICIs) were discontinued, following which the chest CT findings improved. Based on these findings, a diagnosis of ICI‐induced eosinophilic pneumonia was made. Hence, clinicians should be wary of the risk of eosinophilic pneumonia during ICI‐anticancer therapy. John Wiley & Sons Australia, Ltd 2021-01-21 2021-03 /pmc/articles/PMC7919115/ /pubmed/33476070 http://dx.doi.org/10.1111/1759-7714.13848 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Hara, Kanako
Yamasaki, Kei
Tahara, Masahiro
Kimuro, Rieko
Yamaguchi, Yudai
Suzuki, Yu
Kawabata, Hiroki
Kawanami, Toshinori
Fujimoto, Naohiro
Yatera, Kazuhiro
Immune checkpoint inhibitors‐induced eosinophilic pneumonia: A case report
title Immune checkpoint inhibitors‐induced eosinophilic pneumonia: A case report
title_full Immune checkpoint inhibitors‐induced eosinophilic pneumonia: A case report
title_fullStr Immune checkpoint inhibitors‐induced eosinophilic pneumonia: A case report
title_full_unstemmed Immune checkpoint inhibitors‐induced eosinophilic pneumonia: A case report
title_short Immune checkpoint inhibitors‐induced eosinophilic pneumonia: A case report
title_sort immune checkpoint inhibitors‐induced eosinophilic pneumonia: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919115/
https://www.ncbi.nlm.nih.gov/pubmed/33476070
http://dx.doi.org/10.1111/1759-7714.13848
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