Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report

Immune‐checkpoint inhibitors (ICIs) provide a promising treatment option for advanced tumors including small cell lung cancer (SCLC). Nevertheless, in addition to immune‐related adverse events (irAEs), an increased risk of infection including tuberculosis has been previously described. Here, we repo...

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Autores principales: Sirgiovanni, Mattia, Hinterleitner, Clemens, Horger, Marius, Atique, Naushad Bijoy, Lauer, Ulrich M., Zender, Lars, Hinterleitner, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919119/
https://www.ncbi.nlm.nih.gov/pubmed/33458956
http://dx.doi.org/10.1111/1759-7714.13821
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author Sirgiovanni, Mattia
Hinterleitner, Clemens
Horger, Marius
Atique, Naushad Bijoy
Lauer, Ulrich M.
Zender, Lars
Hinterleitner, Martina
author_facet Sirgiovanni, Mattia
Hinterleitner, Clemens
Horger, Marius
Atique, Naushad Bijoy
Lauer, Ulrich M.
Zender, Lars
Hinterleitner, Martina
author_sort Sirgiovanni, Mattia
collection PubMed
description Immune‐checkpoint inhibitors (ICIs) provide a promising treatment option for advanced tumors including small cell lung cancer (SCLC). Nevertheless, in addition to immune‐related adverse events (irAEs), an increased risk of infection including tuberculosis has been previously described. Here, we report a case of long‐term remission of a patient with SCLC after reactivation of lung tuberculosis following ICI therapy. Our case illustrates the complexity of ICI‐associated immune modulation in tuberculosis. Since new lesions in lung cancer patients are commonly associated with tumor progression, infections with mycobacterial tuberculosis may be underdiagnosed in lung cancer.
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spelling pubmed-79191192021-03-05 Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report Sirgiovanni, Mattia Hinterleitner, Clemens Horger, Marius Atique, Naushad Bijoy Lauer, Ulrich M. Zender, Lars Hinterleitner, Martina Thorac Cancer Case Reports Immune‐checkpoint inhibitors (ICIs) provide a promising treatment option for advanced tumors including small cell lung cancer (SCLC). Nevertheless, in addition to immune‐related adverse events (irAEs), an increased risk of infection including tuberculosis has been previously described. Here, we report a case of long‐term remission of a patient with SCLC after reactivation of lung tuberculosis following ICI therapy. Our case illustrates the complexity of ICI‐associated immune modulation in tuberculosis. Since new lesions in lung cancer patients are commonly associated with tumor progression, infections with mycobacterial tuberculosis may be underdiagnosed in lung cancer. John Wiley & Sons Australia, Ltd 2021-01-17 2021-03 /pmc/articles/PMC7919119/ /pubmed/33458956 http://dx.doi.org/10.1111/1759-7714.13821 Text en © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Sirgiovanni, Mattia
Hinterleitner, Clemens
Horger, Marius
Atique, Naushad Bijoy
Lauer, Ulrich M.
Zender, Lars
Hinterleitner, Martina
Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report
title Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report
title_full Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report
title_fullStr Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report
title_full_unstemmed Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report
title_short Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report
title_sort long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919119/
https://www.ncbi.nlm.nih.gov/pubmed/33458956
http://dx.doi.org/10.1111/1759-7714.13821
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