Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus

BACKGROUND: Approximately one third of type 2 diabetes mellitus (T2DM) cases present with diabetic nephropathy (DN), the leading cause of end-stage renal disease. Inflammation plays an important role in T2DM disease and DN pathogenesis. NLRP3 inflammasomes are complexes that regulate interleukin-1B...

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Detalles Bibliográficos
Autores principales: Tsetsos, Fotis, Roumeliotis, Athanasios, Tsekmekidou, Xanthippi, Alexouda, Sophia, Roumeliotis, Stefanos, Theodoridis, Marios, Thodis, Elias, Panagoutsos, Stylianos, Papanas, Nikolaos, Papazoglou, Dimitrios, Kotsa, Kalliopi, Yovos, John G, Maltezos, Efstratios, Passadakis, Ploumis, Paschou, Peristera, Georgitsi, Marianthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919199/
https://www.ncbi.nlm.nih.gov/pubmed/33164551
http://dx.doi.org/10.1177/1479164120970892

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