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Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME(®)
OBJECTIVE: It is well established that higher low-density lipoprotein (LDL)-cholesterol levels are associated with increased cardiovascular risk. We analyzed whether effects of empagliflozin on cardiovascular outcomes varied by different LDL-cholesterol levels at baseline in EMPA-REG OUTCOME. METHOD...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919220/ https://www.ncbi.nlm.nih.gov/pubmed/33307785 http://dx.doi.org/10.1177/1479164120975256 |
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author | Langslet, Gisle Zinman, Bernard Wanner, Christoph Hantel, Stefan Espadero, Rosa-Maria Fitchett, David Johansen, Odd Erik |
author_facet | Langslet, Gisle Zinman, Bernard Wanner, Christoph Hantel, Stefan Espadero, Rosa-Maria Fitchett, David Johansen, Odd Erik |
author_sort | Langslet, Gisle |
collection | PubMed |
description | OBJECTIVE: It is well established that higher low-density lipoprotein (LDL)-cholesterol levels are associated with increased cardiovascular risk. We analyzed whether effects of empagliflozin on cardiovascular outcomes varied by different LDL-cholesterol levels at baseline in EMPA-REG OUTCOME. METHODS: Participants with type 2 diabetes and high cardiovascular risk received empagliflozin (10/25 mg) or placebo in addition to standard of care. We investigated the time to first 3P-MACE, cardiovascular death, hospitalization for heart failure (HHF) and all-cause mortality for empagliflozin versus placebo between baseline LDL-cholesterol categories <1.8, 1.8–<2.2, 2.2– <2.6, 2.6–3.0, and > 3.0 mmol/L, by a Cox regression including the interaction of baseline LDL-cholesterol category and treatment. RESULTS: Of the 7020 participants randomized and treated, 81.0% received lipid lowering therapy (77.0% statins). Mean ± SD LDL-cholesterol was 2.2 ± 0.9 mmol/L, and 38%/18%, had LDL-cholesterol <1.8/>3.0 mmol/L. Age, BMI, and HbA1c levels were balanced between the LDL-cholesterol subgroups, but those in the lowest versus highest group, had more coronary artery disease (83.0% vs 59.9%) and statin treatment (88.2% vs 50.9%). Empagliflozin consistently reduced all outcomes across LDL-cholesterol categories (all interaction p-values > 0.05). CONCLUSION: The beneficial cardiovascular effects of empagliflozin was consistent across higher and lower LDL-cholesterol levels at baseline. |
format | Online Article Text |
id | pubmed-7919220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-79192202021-03-02 Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME(®) Langslet, Gisle Zinman, Bernard Wanner, Christoph Hantel, Stefan Espadero, Rosa-Maria Fitchett, David Johansen, Odd Erik Diab Vasc Dis Res Brief Report OBJECTIVE: It is well established that higher low-density lipoprotein (LDL)-cholesterol levels are associated with increased cardiovascular risk. We analyzed whether effects of empagliflozin on cardiovascular outcomes varied by different LDL-cholesterol levels at baseline in EMPA-REG OUTCOME. METHODS: Participants with type 2 diabetes and high cardiovascular risk received empagliflozin (10/25 mg) or placebo in addition to standard of care. We investigated the time to first 3P-MACE, cardiovascular death, hospitalization for heart failure (HHF) and all-cause mortality for empagliflozin versus placebo between baseline LDL-cholesterol categories <1.8, 1.8–<2.2, 2.2– <2.6, 2.6–3.0, and > 3.0 mmol/L, by a Cox regression including the interaction of baseline LDL-cholesterol category and treatment. RESULTS: Of the 7020 participants randomized and treated, 81.0% received lipid lowering therapy (77.0% statins). Mean ± SD LDL-cholesterol was 2.2 ± 0.9 mmol/L, and 38%/18%, had LDL-cholesterol <1.8/>3.0 mmol/L. Age, BMI, and HbA1c levels were balanced between the LDL-cholesterol subgroups, but those in the lowest versus highest group, had more coronary artery disease (83.0% vs 59.9%) and statin treatment (88.2% vs 50.9%). Empagliflozin consistently reduced all outcomes across LDL-cholesterol categories (all interaction p-values > 0.05). CONCLUSION: The beneficial cardiovascular effects of empagliflozin was consistent across higher and lower LDL-cholesterol levels at baseline. SAGE Publications 2020-12-13 /pmc/articles/PMC7919220/ /pubmed/33307785 http://dx.doi.org/10.1177/1479164120975256 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Brief Report Langslet, Gisle Zinman, Bernard Wanner, Christoph Hantel, Stefan Espadero, Rosa-Maria Fitchett, David Johansen, Odd Erik Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME(®) |
title | Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME(®) |
title_full | Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME(®) |
title_fullStr | Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME(®) |
title_full_unstemmed | Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME(®) |
title_short | Cardiovascular outcomes and LDL-cholesterol levels in EMPA-REG OUTCOME(®) |
title_sort | cardiovascular outcomes and ldl-cholesterol levels in empa-reg outcome(®) |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919220/ https://www.ncbi.nlm.nih.gov/pubmed/33307785 http://dx.doi.org/10.1177/1479164120975256 |
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