Cargando…
Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12)
AIM: To investigate risk factors associated with kidney disorders in patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk. METHODS: In DEVOTE, a cardiovascular outcomes trial, 7637 patients were randomised to insulin degludec (degludec) or insulin glargine 100 units/mL (glargine U100...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919227/ https://www.ncbi.nlm.nih.gov/pubmed/33280425 http://dx.doi.org/10.1177/1479164120970933 |
_version_ | 1783658094827405312 |
---|---|
author | Amod, Aslam Buse, John B McGuire, Darren K Pieber, Thomas R Pop-Busui, Rodica Pratley, Richard E Zinman, Bernard Hansen, Marco Bo Jia, Ting Mark, Thomas Poulter, Neil R |
author_facet | Amod, Aslam Buse, John B McGuire, Darren K Pieber, Thomas R Pop-Busui, Rodica Pratley, Richard E Zinman, Bernard Hansen, Marco Bo Jia, Ting Mark, Thomas Poulter, Neil R |
author_sort | Amod, Aslam |
collection | PubMed |
description | AIM: To investigate risk factors associated with kidney disorders in patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk. METHODS: In DEVOTE, a cardiovascular outcomes trial, 7637 patients were randomised to insulin degludec (degludec) or insulin glargine 100 units/mL (glargine U100), with standard of care. In these exploratory post hoc analyses, serious adverse event reports were searched using Standardised MedDRA(®) Queries related to chronic kidney disease (CKD) or acute kidney injury (AKI). Baseline predictors of CKD, AKI and change in estimated glomerular filtration rate (eGFR) were identified using stepwise selection and Cox or linear regression. RESULTS: Over 2 years, eGFR (mL/min/1.73 m(2)) decline was small and similar between treatments (degludec: 2.70; glargine U100: 2.92). Overall, 97 and 208 patients experienced CKD and AKI events, respectively. A history of heart failure was a risk factor for CKD (hazard ratio [HR] 1.97 [95% confidence interval [CI] 1.41; 2.75]) and AKI (HR 2.28 [95% CI 1.64; 3.17]). A history of hepatic impairment was a significant predictor of CKD (HR 3.28 [95% CI 2.12; 5.07]) and change in eGFR (estimate: −8.59 [95% CI −10.20; −7.00]). CONCLUSION: Our findings indicate that traditional, non-modifiable risk factors for kidney disorders apply to insulin-treated patients with T2D at high CV risk. TRIAL REGISTRATION: NCT01959529 (ClinicalTrials.gov). |
format | Online Article Text |
id | pubmed-7919227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-79192272021-03-02 Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12) Amod, Aslam Buse, John B McGuire, Darren K Pieber, Thomas R Pop-Busui, Rodica Pratley, Richard E Zinman, Bernard Hansen, Marco Bo Jia, Ting Mark, Thomas Poulter, Neil R Diab Vasc Dis Res Original Article AIM: To investigate risk factors associated with kidney disorders in patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk. METHODS: In DEVOTE, a cardiovascular outcomes trial, 7637 patients were randomised to insulin degludec (degludec) or insulin glargine 100 units/mL (glargine U100), with standard of care. In these exploratory post hoc analyses, serious adverse event reports were searched using Standardised MedDRA(®) Queries related to chronic kidney disease (CKD) or acute kidney injury (AKI). Baseline predictors of CKD, AKI and change in estimated glomerular filtration rate (eGFR) were identified using stepwise selection and Cox or linear regression. RESULTS: Over 2 years, eGFR (mL/min/1.73 m(2)) decline was small and similar between treatments (degludec: 2.70; glargine U100: 2.92). Overall, 97 and 208 patients experienced CKD and AKI events, respectively. A history of heart failure was a risk factor for CKD (hazard ratio [HR] 1.97 [95% confidence interval [CI] 1.41; 2.75]) and AKI (HR 2.28 [95% CI 1.64; 3.17]). A history of hepatic impairment was a significant predictor of CKD (HR 3.28 [95% CI 2.12; 5.07]) and change in eGFR (estimate: −8.59 [95% CI −10.20; −7.00]). CONCLUSION: Our findings indicate that traditional, non-modifiable risk factors for kidney disorders apply to insulin-treated patients with T2D at high CV risk. TRIAL REGISTRATION: NCT01959529 (ClinicalTrials.gov). SAGE Publications 2020-12-06 /pmc/articles/PMC7919227/ /pubmed/33280425 http://dx.doi.org/10.1177/1479164120970933 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Amod, Aslam Buse, John B McGuire, Darren K Pieber, Thomas R Pop-Busui, Rodica Pratley, Richard E Zinman, Bernard Hansen, Marco Bo Jia, Ting Mark, Thomas Poulter, Neil R Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12) |
title | Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12) |
title_full | Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12) |
title_fullStr | Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12) |
title_full_unstemmed | Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12) |
title_short | Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12) |
title_sort | risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: an exploratory analysis (devote 12) |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919227/ https://www.ncbi.nlm.nih.gov/pubmed/33280425 http://dx.doi.org/10.1177/1479164120970933 |
work_keys_str_mv | AT amodaslam riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT busejohnb riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT mcguiredarrenk riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT pieberthomasr riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT popbusuirodica riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT pratleyricharde riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT zinmanbernard riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT hansenmarcobo riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT jiating riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT markthomas riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT poulterneilr riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 AT riskfactorsforkidneydisordersinpatientswithtype2diabetesathighcardiovascularriskanexploratoryanalysisdevote12 |