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Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury
Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, millions of people have been infected and died worldwide. However, no drug has been approved for the treatment of this disease and its complications, which urges the need for finding novel therapeutic agents to combat. Among...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919380/ https://www.ncbi.nlm.nih.gov/pubmed/33658931 http://dx.doi.org/10.3389/fphar.2020.588467 |
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author | Majnooni, Mohammad Bagher Fakhri, Sajad Shokoohinia, Yalda Kiyani, Narges Stage, Katrina Mohammadi, Pantea Gravandi, Mohammad Mehdi Farzaei, Mohammad Hosein Echeverría, Javier |
author_facet | Majnooni, Mohammad Bagher Fakhri, Sajad Shokoohinia, Yalda Kiyani, Narges Stage, Katrina Mohammadi, Pantea Gravandi, Mohammad Mehdi Farzaei, Mohammad Hosein Echeverría, Javier |
author_sort | Majnooni, Mohammad Bagher |
collection | PubMed |
description | Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, millions of people have been infected and died worldwide. However, no drug has been approved for the treatment of this disease and its complications, which urges the need for finding novel therapeutic agents to combat. Among the complications due to COVID-19, lung injury has attained special attention. Besides, phytochemicals have shown prominent anti-inflammatory effects and thus possess significant effects in reducing lung injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, the prevailing evidence reveales the antiviral effects of those phytochemicals, including anti-SARS-CoV activity, which could pave the road in providing suitable lead compounds in the treatment of COVID-19. In the present study, candidate phytochemicals and related mechanisms of action have been shown in the treatment/protection of lung injuries induced by various methods. In terms of pharmacological mechanism, phytochemicals have shown potential inhibitory effects on inflammatory and oxidative pathways/mediators, involved in the pathogenesis of lung injury during COVID-19 infection. Also, a brief overview of phytochemicals with anti-SARS-CoV-2 compounds has been presented. |
format | Online Article Text |
id | pubmed-7919380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79193802021-03-02 Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury Majnooni, Mohammad Bagher Fakhri, Sajad Shokoohinia, Yalda Kiyani, Narges Stage, Katrina Mohammadi, Pantea Gravandi, Mohammad Mehdi Farzaei, Mohammad Hosein Echeverría, Javier Front Pharmacol Pharmacology Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, millions of people have been infected and died worldwide. However, no drug has been approved for the treatment of this disease and its complications, which urges the need for finding novel therapeutic agents to combat. Among the complications due to COVID-19, lung injury has attained special attention. Besides, phytochemicals have shown prominent anti-inflammatory effects and thus possess significant effects in reducing lung injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, the prevailing evidence reveales the antiviral effects of those phytochemicals, including anti-SARS-CoV activity, which could pave the road in providing suitable lead compounds in the treatment of COVID-19. In the present study, candidate phytochemicals and related mechanisms of action have been shown in the treatment/protection of lung injuries induced by various methods. In terms of pharmacological mechanism, phytochemicals have shown potential inhibitory effects on inflammatory and oxidative pathways/mediators, involved in the pathogenesis of lung injury during COVID-19 infection. Also, a brief overview of phytochemicals with anti-SARS-CoV-2 compounds has been presented. Frontiers Media S.A. 2020-11-18 /pmc/articles/PMC7919380/ /pubmed/33658931 http://dx.doi.org/10.3389/fphar.2020.588467 Text en Copyright © 2020 Majnooni, Fakhri, Shokoohinia, Kiyani, Stage, Mohammadi, Gravand, Farzaei and Echeverria. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Majnooni, Mohammad Bagher Fakhri, Sajad Shokoohinia, Yalda Kiyani, Narges Stage, Katrina Mohammadi, Pantea Gravandi, Mohammad Mehdi Farzaei, Mohammad Hosein Echeverría, Javier Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury |
title | Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury |
title_full | Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury |
title_fullStr | Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury |
title_full_unstemmed | Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury |
title_short | Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury |
title_sort | phytochemicals: potential therapeutic interventions against coronavirus-associated lung injury |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919380/ https://www.ncbi.nlm.nih.gov/pubmed/33658931 http://dx.doi.org/10.3389/fphar.2020.588467 |
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