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Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex

Nuclear Argonaute proteins, guided by their bound small RNAs to nascent target transcripts, mediate cotranscriptional silencing of transposons and repetitive genomic loci through heterochromatin formation. The molecular mechanisms involved in this process are incompletely understood. Here, we show t...

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Detalles Bibliográficos
Autores principales: Schnabl, Jakob, Wang, Juncheng, Hohmann, Ulrich, Gehre, Maja, Batki, Julia, Andreev, Veselin I., Purkhauser, Kim, Fasching, Nina, Duchek, Peter, Novatchkova, Maria, Mechtler, Karl, Plaschka, Clemens, Patel, Dinshaw J., Brennecke, Julius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919418/
https://www.ncbi.nlm.nih.gov/pubmed/33574069
http://dx.doi.org/10.1101/gad.347989.120