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SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development

Globally, SARS-CoV-2 has emerged as threat to life and economy. Researchers are trying to find a cure against this pathogen but without much success. Several attempts have been made to understand the atomic level details of SARS-CoV-2 in the past few months. However, one review with all structural d...

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Autores principales: Kaur, Mandeep, Sharma, Akanksha, Kumar, Santosh, Singh, Gurpal, Barnwal, Ravi P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919520/
https://www.ncbi.nlm.nih.gov/pubmed/33662418
http://dx.doi.org/10.1016/j.ijbiomac.2021.02.212
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author Kaur, Mandeep
Sharma, Akanksha
Kumar, Santosh
Singh, Gurpal
Barnwal, Ravi P.
author_facet Kaur, Mandeep
Sharma, Akanksha
Kumar, Santosh
Singh, Gurpal
Barnwal, Ravi P.
author_sort Kaur, Mandeep
collection PubMed
description Globally, SARS-CoV-2 has emerged as threat to life and economy. Researchers are trying to find a cure against this pathogen but without much success. Several attempts have been made to understand the atomic level details of SARS-CoV-2 in the past few months. However, one review with all structural details for drug and vaccine development has been missing. Hence, this review aims to summarize key functional roles played by various domains of SARS-CoV-2 genome during its entry into the host, replication, repression of host immune response and overall viral life cycle. Additionally, various proteins of SARS-CoV-2 for finding a potent inhibitor have also been highlighted. To mitigate this deadly virus, an understanding of atomic level information, pathogenicity mechanisms and functions of different proteins in causing the infection is imperative. Thus, these structural details would finally pave the way for development of a potential drug/vaccine against the disease caused by SARS-CoV-2.
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spelling pubmed-79195202021-03-01 SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development Kaur, Mandeep Sharma, Akanksha Kumar, Santosh Singh, Gurpal Barnwal, Ravi P. Int J Biol Macromol Review Globally, SARS-CoV-2 has emerged as threat to life and economy. Researchers are trying to find a cure against this pathogen but without much success. Several attempts have been made to understand the atomic level details of SARS-CoV-2 in the past few months. However, one review with all structural details for drug and vaccine development has been missing. Hence, this review aims to summarize key functional roles played by various domains of SARS-CoV-2 genome during its entry into the host, replication, repression of host immune response and overall viral life cycle. Additionally, various proteins of SARS-CoV-2 for finding a potent inhibitor have also been highlighted. To mitigate this deadly virus, an understanding of atomic level information, pathogenicity mechanisms and functions of different proteins in causing the infection is imperative. Thus, these structural details would finally pave the way for development of a potential drug/vaccine against the disease caused by SARS-CoV-2. Elsevier B.V. 2021-05-15 2021-03-01 /pmc/articles/PMC7919520/ /pubmed/33662418 http://dx.doi.org/10.1016/j.ijbiomac.2021.02.212 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Kaur, Mandeep
Sharma, Akanksha
Kumar, Santosh
Singh, Gurpal
Barnwal, Ravi P.
SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development
title SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development
title_full SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development
title_fullStr SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development
title_full_unstemmed SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development
title_short SARS-CoV-2: Insights into its structural intricacies and functional aspects for drug and vaccine development
title_sort sars-cov-2: insights into its structural intricacies and functional aspects for drug and vaccine development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919520/
https://www.ncbi.nlm.nih.gov/pubmed/33662418
http://dx.doi.org/10.1016/j.ijbiomac.2021.02.212
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