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Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions

Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics. The redox status regulates the level of reactive oxygen and...

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Autores principales: Ayuso, Pedro, García-Martín, Elena, Agúndez, José A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919686/
https://www.ncbi.nlm.nih.gov/pubmed/33672092
http://dx.doi.org/10.3390/antiox10020294
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author Ayuso, Pedro
García-Martín, Elena
Agúndez, José A. G.
author_facet Ayuso, Pedro
García-Martín, Elena
Agúndez, José A. G.
author_sort Ayuso, Pedro
collection PubMed
description Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics. The redox status regulates the level of reactive oxygen and nitrogen species (RONS). RONS interplay and modulate the action of diverse biomolecules, such as inflammatory mediators and drugs. In this review, we address the role of the redox status in the initiation, as well as in the resolution of inflammatory processes involved in drug hypersensitivity reactions. We summarize the association findings between drug hypersensitivity reactions and variants in the genes that encode the enzymes related to the redox system such as enzymes related to glutathione: Glutathione S-transferase (GSTM1, GSTP, GSTT1) and glutathione peroxidase (GPX1), thioredoxin reductase (TXNRD1 and TXNRD2), superoxide dismutase (SOD1, SOD2, and SOD3), catalase (CAT), aldo-keto reductase (AKR), and the peroxiredoxin system (PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6). Based on current evidence, the most relevant candidate redox genes related to hypersensitivity drug reactions are GSTM1, TXNRD1, SOD1, and SOD2. Increasing the understanding of pharmacogenetics in drug hypersensitivity reactions will contribute to the development of early diagnostic or prognosis tools, and will help to diminish the occurrence and/or the severity of these reactions.
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spelling pubmed-79196862021-03-02 Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions Ayuso, Pedro García-Martín, Elena Agúndez, José A. G. Antioxidants (Basel) Review Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics. The redox status regulates the level of reactive oxygen and nitrogen species (RONS). RONS interplay and modulate the action of diverse biomolecules, such as inflammatory mediators and drugs. In this review, we address the role of the redox status in the initiation, as well as in the resolution of inflammatory processes involved in drug hypersensitivity reactions. We summarize the association findings between drug hypersensitivity reactions and variants in the genes that encode the enzymes related to the redox system such as enzymes related to glutathione: Glutathione S-transferase (GSTM1, GSTP, GSTT1) and glutathione peroxidase (GPX1), thioredoxin reductase (TXNRD1 and TXNRD2), superoxide dismutase (SOD1, SOD2, and SOD3), catalase (CAT), aldo-keto reductase (AKR), and the peroxiredoxin system (PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, PRDX6). Based on current evidence, the most relevant candidate redox genes related to hypersensitivity drug reactions are GSTM1, TXNRD1, SOD1, and SOD2. Increasing the understanding of pharmacogenetics in drug hypersensitivity reactions will contribute to the development of early diagnostic or prognosis tools, and will help to diminish the occurrence and/or the severity of these reactions. MDPI 2021-02-15 /pmc/articles/PMC7919686/ /pubmed/33672092 http://dx.doi.org/10.3390/antiox10020294 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ayuso, Pedro
García-Martín, Elena
Agúndez, José A. G.
Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions
title Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions
title_full Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions
title_fullStr Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions
title_full_unstemmed Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions
title_short Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions
title_sort variability of the genes involved in the cellular redox status and their implication in drug hypersensitivity reactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919686/
https://www.ncbi.nlm.nih.gov/pubmed/33672092
http://dx.doi.org/10.3390/antiox10020294
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