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Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection?

We describe a unique case of fulminant myocarditis in a patient with presumed SARS-CoV-2 reinfection. Patient had initial infection 4 months backand had COVID-19 antibody at the time of presentation. Endomyocardial biopsy showed lymphocytic myocarditis, that is usually seen in viral myocarditis. The...

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Autores principales: Yeleti, Ramya, Guglin, Maya, Saleem, Kashif, Adigopula, Sasikanth V, Sinha, Anjan, Upadhyay, Smrity, Everett, Jeffrey E, Ballut, Kareem, Uppuluri, Sarada, Rao, Roopa A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919708/
https://www.ncbi.nlm.nih.gov/pubmed/33615872
http://dx.doi.org/10.2217/fca-2020-0237
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author Yeleti, Ramya
Guglin, Maya
Saleem, Kashif
Adigopula, Sasikanth V
Sinha, Anjan
Upadhyay, Smrity
Everett, Jeffrey E
Ballut, Kareem
Uppuluri, Sarada
Rao, Roopa A
author_facet Yeleti, Ramya
Guglin, Maya
Saleem, Kashif
Adigopula, Sasikanth V
Sinha, Anjan
Upadhyay, Smrity
Everett, Jeffrey E
Ballut, Kareem
Uppuluri, Sarada
Rao, Roopa A
author_sort Yeleti, Ramya
collection PubMed
description We describe a unique case of fulminant myocarditis in a patient with presumed SARS-CoV-2 reinfection. Patient had initial infection 4 months backand had COVID-19 antibody at the time of presentation. Endomyocardial biopsy showed lymphocytic myocarditis, that is usually seen in viral myocarditis. The molecular diagnostic testing of the endomyocardial biopsy for cardiotropic viruses was positive for Parvovirus and negative for SARS-CoV-2. Authors highly suspect co-infection of SARS-CoV-2 and Parvovirus, that possibly triggered the immune cascade resulting in fulminant myocarditis. Patient was hemodynamically unstable with ventricular tachycardia and was supported on VA ECMO and Impella CP. There was impressive recovery of left ventricular function within 48 hours, leading to decannulation of VA ECMO in 72 h. This unique case was written by the survivor herself.
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spelling pubmed-79197082021-03-01 Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection? Yeleti, Ramya Guglin, Maya Saleem, Kashif Adigopula, Sasikanth V Sinha, Anjan Upadhyay, Smrity Everett, Jeffrey E Ballut, Kareem Uppuluri, Sarada Rao, Roopa A Future Cardiol Case Report We describe a unique case of fulminant myocarditis in a patient with presumed SARS-CoV-2 reinfection. Patient had initial infection 4 months backand had COVID-19 antibody at the time of presentation. Endomyocardial biopsy showed lymphocytic myocarditis, that is usually seen in viral myocarditis. The molecular diagnostic testing of the endomyocardial biopsy for cardiotropic viruses was positive for Parvovirus and negative for SARS-CoV-2. Authors highly suspect co-infection of SARS-CoV-2 and Parvovirus, that possibly triggered the immune cascade resulting in fulminant myocarditis. Patient was hemodynamically unstable with ventricular tachycardia and was supported on VA ECMO and Impella CP. There was impressive recovery of left ventricular function within 48 hours, leading to decannulation of VA ECMO in 72 h. This unique case was written by the survivor herself. Future Medicine Ltd 2021-02-22 2021-01 /pmc/articles/PMC7919708/ /pubmed/33615872 http://dx.doi.org/10.2217/fca-2020-0237 Text en © 2021 Future Medicine Ltd This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Case Report
Yeleti, Ramya
Guglin, Maya
Saleem, Kashif
Adigopula, Sasikanth V
Sinha, Anjan
Upadhyay, Smrity
Everett, Jeffrey E
Ballut, Kareem
Uppuluri, Sarada
Rao, Roopa A
Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection?
title Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection?
title_full Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection?
title_fullStr Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection?
title_full_unstemmed Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection?
title_short Fulminant myocarditis: COVID or not COVID? Reinfection or co-infection?
title_sort fulminant myocarditis: covid or not covid? reinfection or co-infection?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919708/
https://www.ncbi.nlm.nih.gov/pubmed/33615872
http://dx.doi.org/10.2217/fca-2020-0237
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